cyclopropylhydrazine hydrochloride
- Product Name
- cyclopropylhydrazine hydrochloride
- CAS No.
- 213764-25-1
- Chemical Name
- cyclopropylhydrazine hydrochloride
- Synonyms
- EOS-61146;1-Cyclopropylhydrazine HCl;cyclohydrazine (Hydrochloride);cyclopropylhydrazinehydrochlorid;cyclopropylhydrazine hydrochloride;1-cyclopropylhydrazine hydrochloride;cyclopropylhydrazine hydrogen chloride;Cyclopropylhydrazine monohydrochloride;Cyclopropylhydrazine hydrochloride (1:1);Hydrazine,cyclopropyl-,Monohydrochloride
- CBNumber
- CB02614843
- Molecular Formula
- C3H9ClN2
- Formula Weight
- 108.56996
- MOL File
- 213764-25-1.mol
cyclopropylhydrazine hydrochloride Property
- Melting point:
- > 97° C (dec.)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C3H8N2.ClH/c4-5-3-1-2-3;/h3,5H,1-2,4H2;1H
- InChIKey
- SDYFTMROHZCYSK-UHFFFAOYSA-N
- SMILES
- N(C1CC1)N.[H]Cl
- CAS DataBase Reference
- 213764-25-1
Safety
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- C998203
- Product name
- CyclopropylhydrazineHydrochloride
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- AK-77851
- Product name
- Cyclopropylhydrazinehydrochloride
- Purity
- 95%
- Packaging
- 250mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- CS-B1049
- Product name
- Cyclopropylhydrazinehydrochloride
- Purity
- >96.0%
- Packaging
- 250mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- 093290
- Product name
- Cyclopropylhydrazine hydrochloride
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $98
- Updated
- 2021/12/16
- Product number
- CS-B1049
- Product name
- Cyclopropylhydrazinehydrochloride
- Purity
- >96.0%
- Packaging
- 1g
- Price
- $135
- Updated
- 2021/12/16
cyclopropylhydrazine hydrochloride Chemical Properties,Usage,Production
Uses
Cyclopropylhydrazine Hydrochloride can be used as PRMT5 inhibitors as pharmaceutically acceptable salts.
Synthesis
Synthesis of N-Boc-cyclopropylhydrazine:
Cyclopropylamine (59.3 g, 1.04 mol, 10 eq.), dichloromethane (180 mL), and N-methylmorpholine (NMM, 11.5 g, 0.114 mol, 1.1 eq.) were added sequentially to a 500 mL three-necked flask, and the reaction was cooled down to -5~0 ??C in an ice-salt bath with the addition in batches of solid N Boc-O-tosylhydroxylamine (BocHNOTs, 29.8 g, 0.104 mol, 1.0 eq.), after addition, the reaction was maintained at 0 ??C to continue for 2 h. The reaction was followed by TLC to monitor the reaction endpoint at room temperature (below 20 ??C) overnight. Stop the reaction, concentrate dry, add dichloromethane and water to the crude product, after layering, collect the organic phase, the aqueous layer was then extracted twice with dichloromethane, combine the organic phases, drying, filtration, concentrated to obtain the crude product (21g, theoretical 16.4g), the crude product was pulped with petroleum ether to obtain a light yellow solid (11g, 67% yield), melting point 105.4~106.2??C.
Preparation of cyclopropylhydrazine hydrochloride:
To a 100 mL three-necked flask was added N-Boc-cyclopropylhydrazine (5 g, 29 mmoL, 1.0 eq.), and concentrated hydrochloric acid (10 mL) was added dropwise in an ice-water bath. After dropping, the reaction was carried out at room temperature (20~25??C) overnight (17~20 hours), the end of the reaction was monitored by TLC tracking, the reaction solution was decolorized by the addition of activated charcoal, filtered, and the aqueous phase was concentrated to obtain 10g of crude product, which was recrystallized from ethanol to obtain white crystals (2.4g, 76% yield), melting point 131.6~132.6??C.cyclopropylhydrazine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from cyclopropylhydrazine hydrochloride manufacturers
- Product
- cyclopropylhydrazine hydrochloride 213764-25-1
- Price
- US $49.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2025-09-05
- Product
- cyclopropylhydrazine hydrochloride 213764-25-1
- Price
- US $1.00-4.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2025-09-04
- Product
- cyclopropylhydrazine hydrochloride 213764-25-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-05-09