Cyclopropylboronic acid
- Product Name
- Cyclopropylboronic acid
- CAS No.
- 411235-57-9
- Chemical Name
- Cyclopropylboronic acid
- Synonyms
- Cyclopropylboronic;Cyclopropaneboronic acid;AKOS BRN-0457;Boronocyclopropane;Cyclopropylboronica;CYCLOROPYLBORONIC ACID;CYCLOPROPYLBORONIC ACID;B-Cyclopropylboronic Acid;Boronic acid, cyclopropyl-;Cyclopropylboronic acid 95%
- CBNumber
- CB3133570
- Molecular Formula
- C3H7BO2
- Formula Weight
- 85.9
- MOL File
- 411235-57-9.mol
Cyclopropylboronic acid Property
- Melting point:
- 90-95 °C (lit.)
- Boiling point:
- 205.1±23.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO
- pka
- 10.49±0.20(Predicted)
- form
- Powder
- color
- white
- Sensitive
- moisture sensitive
- InChI
- InChI=1S/C3H7BO2/c5-4(6)3-1-2-3/h3,5-6H,1-2H2
- InChIKey
- WLVKDFJTYKELLQ-UHFFFAOYSA-N
- SMILES
- C1CC1B(O)O
- CAS DataBase Reference
- 411235-57-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,T
- Risk Statements
- 22-36-61-60-36/37/38
- Safety Statements
- 26-36-45-53-37/39
- WGK Germany
- 3
- TSCA
- No
- HazardClass
- IRRITANT, IRRITANT-HARMFUL
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P201Obtain special instructions before use.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 597988
- Product name
- Cyclopropylboronic acid
- Packaging
- 1g
- Price
- $74.47
- Updated
- 2025/07/31
- Product number
- 597988
- Product name
- Cyclopropylboronic acid
- Packaging
- 5g
- Price
- $169.76
- Updated
- 2025/07/31
- Product number
- 05-0440
- Product name
- Cyclopropylboronic acid, min. 97%
- Packaging
- 1g
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 05-0440
- Product name
- Cyclopropylboronic acid, min. 97%
- Packaging
- 5g
- Price
- $294
- Updated
- 2024/03/01
- Product number
- 597988
- Product name
- Cyclopropylboronic acid
- Packaging
- 25g
- Price
- $779
- Updated
- 2025/07/31
Cyclopropylboronic acid Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
Cyclopropylboronic Acid is an organoboronic acid commonly used in highly efficient Suzuki coupling reactions.
Uses
Reagent used for• ;Microwave-assisted copper(II)-catalyzed N-cyclopropylation1• ;Nickel- and copper-catalyzed Suzuki-Miyaura coupling reaction of arenes2• ;Palladacycle-catalyzed Suzuki-cross coupling of aryl halides with cyclopropylboronic acid3• ;Palladium(0)-catalyzed cyclopropane C-H bond functionalization4• ;Palladium-catalyzed decarboxylative coupling5• ;Palladium-catalyzed ligand-directed oxidative functionalization of cyclopropanes6• ;Palladium-catalyzed Suzuki coupling reaction7Reagent used in Preparation of• ;Diaryl ketones by arylation
Uses
suzuki reaction
Synthesis
121-43-7
23719-80-4
411235-57-9
Cyclopropylmagnesium bromide (0.5 M in THF, 25 mL, 12.5 mmol) was added dropwise to a stirred solution of trimethylborate (1.69 g, 1.81 mL, 16.25 mmol) in tetrahydrofuran (7 mL) under nitrogen protection at -78°C. A white precipitate was observed during the reaction. A white precipitate was observed to form during the reaction. after 1 h, the reaction system was slowly warmed to room temperature and stirring was continued overnight. Upon completion of the reaction, the reaction was quenched with 2.0 N aqueous hydrochloric acid (20 mL) and the mixture was stirred for 1 hr. Subsequently, the reaction mixture was extracted with dichloromethane (15 mL) and the aqueous phase was back-extracted with deionized water (2 x 15 mL). All aqueous phases were combined and extracted with methyl tert-butyl ether (4 x 40 mL). The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give a white solid product. Two recrystallizations were carried out via a solvent mixture of dichloromethane and hexane, resulting in 252-297 mg of white solid product in 27% yield. The product was characterized by NMR hydrogen spectroscopy (250 MHz, CDCl3): δ 0.56-0.50 (2H, m, CH2), 0.42-0.40 (2H, m, CH2), -0.08 to -0.20 (1H, m, CH).
References
[1] Patent: WO2004/56788, 2004, A1. Location in patent: Page 51
Cyclopropylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cyclopropylboronic acid manufacturers
- Product
- Cyclopropylboronic acid 411235-57-9
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-07-02
- Product
- Cyclopropylboronic acid 411235-57-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-20
- Product
- Cyclopropylboronic acid 411235-57-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22