ChemicalBook > CAS DataBase List > DL-4-Chlorophenylalanine

DL-4-Chlorophenylalanine

Product Name
DL-4-Chlorophenylalanine
CAS No.
7424-00-2
Chemical Name
DL-4-Chlorophenylalanine
Synonyms
PCP;P-CHLOROPHENYLALANINE;Fenclonine;4-CHLORO-DL-PHENYLALANINE;2-amino-3-(4-chlorophenyl)propanoic acid;2-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID;c-pal;-4-ChL;cp10,188;NSC-77370
CBNumber
CB0261841
Molecular Formula
C9H10ClNO2
Formula Weight
199.63
MOL File
7424-00-2.mol
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DL-4-Chlorophenylalanine Property

Melting point:
>240 °C (dec.)(lit.)
Boiling point:
339.5±32.0 °C(Predicted)
Density 
1.2409 (rough estimate)
refractive index 
1.5790 (estimate)
storage temp. 
room temp
solubility 
Aqueous Acid (Slightly), Methanol (Slightly)
form 
Powder
pka
pK1: 2.08(+1);pK2: 8.96(0) (25°C)
color 
White to almost white
Water Solubility 
slightly soluble
BRN 
2805758
CAS DataBase Reference
7424-00-2(CAS DataBase Reference)
EPA Substance Registry System
4-Chlorophenylalanine (7424-00-2)
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Safety

Hazard Codes 
T
Risk Statements 
25-43
Safety Statements 
36/37-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
AY4390010
TSCA 
Yes
HS Code 
29224985
Hazardous Substances Data
7424-00-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C6506
Product name
4-Chloro-DL-phenylalanine
Packaging
5g
Price
$148
Updated
2024/03/01
Sigma-Aldrich
Product number
C6506
Product name
4-Chloro-DL-phenylalanine
Packaging
25g
Price
$547
Updated
2024/03/01
TCI Chemical
Product number
C0253
Product name
4-Chloro-DL-phenylalanine
Purity
>98.0%(T)
Packaging
1g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
C0253
Product name
4-Chloro-DL-phenylalanine
Purity
>98.0%(T)
Packaging
25g
Price
$248
Updated
2024/03/01
Alfa Aesar
Product number
A13323
Product name
4-Chloro-DL-phenylalanine, 98+%
Packaging
10g
Price
$90.3
Updated
2024/03/01
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DL-4-Chlorophenylalanine Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

An irreversible tryptophan hydroxylase inhibitor.

Uses

4-Chloro-DL-phenylalanine is an irreversible tryptophan hydroxylase inhibitor that depletes serotonin in the brain.

Uses

4-Chloro-DL-phenylalanine has been used:

  • as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish
  • to induce insomnia in rat models
  • used to treat embryos to examine its effect on serotonin
  • for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
  • to feed flies to explore serotonin effect

Definition

ChEBI: 2-amino-3-(4-chlorophenyl)propanoic acid is a phenylalanine derivative.

Biological Activity

4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.

Biochem/physiol Actions

4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.

Safety Profile

An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx and Cl-.

in vivo

4-Chloro-DL-phenylalanine(PCPA) markedly attenuates MCT(monocrotaline)-induced pulmonary vascular remodeling and lung inflammation, inhibits the expression of Tph-1 and SERT and suppresses the expression of MMP-2/-9, TIMP-1/-2, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1). PCPA inhibits 5-HT by suppressing Tph-1, regulating SERT and the serotonin downstream signaling pathway.

storage

Room temperature

DL-4-Chlorophenylalanine Preparation Products And Raw materials

Raw materials

Preparation Products

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DL-4-Chlorophenylalanine Suppliers

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View Lastest Price from DL-4-Chlorophenylalanine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
DL-4-Chlorophenylalanine 7424-00-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Chloro-DL-phenylalanine 7424-00-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
DL-4-Chlorophenylalanine 7424-00-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons
Release date
2020-03-04

7424-00-2, DL-4-ChlorophenylalanineRelated Search:

DL-O-CHLOROPHENYLALANINE DL-P-CHLOROPHENYLALANINE METHYL ESTER*HY,DL-4-CHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE,DL-P-CHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE DL-PENICILLAMINE 2-FLUORO-DL-PHENYLALANINE 4-Iodo-DL-phenylalanine 4-BROMO-DL-PHENYLALANINE 3-(3-Hydroxyphenyl)-DL-alanine DL-4-Cyanophenylalanine 2-AMINO-3-(3-METHOXY-PHENYL)-PROPIONIC ACID 2-Bromo-DL-Phenylalanine DL-3-(4-Fluorophenyl)alanine L-4-Chlorophenylalanine DL-4-CHLOROPHENYLALANINE ETHYL ESTER HYDROCHLORIDE,DL-P-CHLOROPHENYLALANINE ETHYL ESTER HYDROCHLORIDE BOC-DL-4-CHLOROPHENYLALANINE FMOC-DL-2-CHLOROPHENYLALANINE FMOC-DL-3-CHLOROPHENYLALANINE FMOC-DL-4-CHLOROPHENYLALANINE CBZ-DL-4-CHLOROPHENYLALANINE

  • (±)-3-(4-Chlorophenyl)-2-aminopropanoic acid
  • NSC-77370
  • DL-4-Chloro-phe-OH
  • DL-Phe(4-Cl)-OH 4-Chloro-DL-Phenylalanine
  • H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA
  • 4-Chloro-DL-phenylalanine, 98+%
  • DL-4-Chlorophenylalanine, 98+%, 98+%
  • DL-2-Amino-3-(4-chloro-phenyl)-propionic acid
  • 4-Chloro-DL-phenylalanine (PCPA)
  • Fenchlonine(PCPA)
  • 2-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID
  • 4-CHLORO-DL-PHENYLALANINE
  • 4-CHLOROPHENYLALANINE
  • DL-4-CHLOROPHENYLALANINE
  • DL-P-CHLOROPHENYLALANINE
  • fenclonin
  • (RS)-2-Amino-3-(4-chlorophenyl)propionic acid
  • 4-Chloro-DL-phenylalanine≥ 99% (HPLC)
  • Fenclonine
  • (+/-)-P-CHLOROPHENYLALANINE, (P-CPA) CAU SES DEPLETION OF S
  • DL-P-CHLOROPHENYLALANINE CRYSTALLINE
  • 4-Chloro-Dl-Phenylalanine,>99%
  • 2-amino-3-(4-chlorophenyl)propanoic acid
  • 3-(4-CHLOROPHENYL)ALANINE,DL-
  • DL-Phe(4-Cl)-OH
  • 3-(4-Chlorophenyl)-DL-alanine
  • DL-4-Chlorophenylalanine, 98+%
  • PCP, PCPA
  • (2R)-2-Azaniumyl-3-(4-chlorophenyl)propanoate
  • Alanine, 3-(p-chlorophenyl)-
  • 3-(p-chlorophenyl)-DL-alanine
  • P-chloro benzoic acetate
  • (2S)-2-ammonio-3-(4-chlorophenyl)propanoate
  • (+-)-p-chlorphenylalanine
  • cp10,188
  • c-pal
  • H-DL-PHE(4-CL)-OH
  • LABOTEST-BB LT00453604
  • H-P-CHLORO-DL-PHE-OH
  • TIMTEC-BB SBB003551
  • PCP
  • P-CHLOROPHENYLALANINE
  • P-CHLORO-DL-PHENYLALANINE
  • fenchlonine
  • 4-Chloro-DL-phenylalanine &gt
  • Chloro DL
  • Phenylalanine, 4-chloro-
  • -4-ChL
  • DL-4-Chlorophenylalanine USP/EP/BP
  • p-Chlorophenylalanin
  • Fenclonine (PCPA
  • Contezolid Impurity 9
  • 4-Chloro-DL-phenylalanine, ≥ 98.0%
  • 7424-00-2
  • 7724-00-2
  • Peptide Synthesis
  • Phenylalanine Derivatives
  • Unnatural Amino Acid Derivatives