CMX 001
- Product Name
- CMX 001
- CAS No.
- 444805-28-1
- Chemical Name
- CMX 001
- Synonyms
- Brincidofovir (CMX001);CMX 001;HDP-CDV;CS-2275;HDP-HPMPC;HDP-cidofovir;Brincidofovir;CMX 001 - Bio-X ?;CMX001(Brincidofovir);Fampridine Impurity 23
- CBNumber
- CB02627690
- Molecular Formula
- C27H52N3O7P
- Formula Weight
- 561.69
- MOL File
- 444805-28-1.mol
CMX 001 Property
- Melting point:
- > 177° C (dec.)
- Boiling point:
- 688.6±65.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly, Sonicated), Ethanol (Slightly, Heated, Sonicated), Methanol (Sli
- form
- Solid
- pka
- 2.40±0.10(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChIKey
- WXJFKKQWPMNTIM-VWLOTQADSA-N
- SMILES
- P(CO[C@H](CO)CN1C(=O)N=C(N)C=C1)(=O)(O)OCCCOCCCCCCCCCCCCCCCC
N-Bromosuccinimide Price
- Product number
- SML3155
- Product name
- Brincidofovir
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $81.2
- Updated
- 2025/07/31
- Product number
- SML3155
- Product name
- Brincidofovir
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $328
- Updated
- 2025/07/31
- Product number
- B677550
- Product name
- Brincidofovir
- Packaging
- 10mg
- Price
- $945
- Updated
- 2021/12/16
- Product number
- B677550
- Product name
- Brincidofovir
- Packaging
- 25mg
- Price
- $2100
- Updated
- 2021/12/16
- Product number
- API0013857
- Product name
- CMX-001
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.06
- Updated
- 2021/12/16
CMX 001 Chemical Properties,Usage,Production
Uses
Brincidofovir is an antiviral inhibitor, working against BK polymavirus replication in primary human urothelial cells. Cytostatic, cytotoxic agent.
Biological Activity
cmx001 is a broad spectrum antiviral agent [1].cmx001 has been reported to be active in vitro against a broad range of viruses from all five families of dsdna viruses infecting human with ec50 values of 0.02μm, 0.0004μm, 17μm , 0.045μm and 0.07μm for adenovirus, herpesvirus, papillomavirus, polyomavirus and orthopoxvirus, respectively. in addition, cmx001 has been revealed to arrest disease progression by inhibiting viral dna replication and thereby reducing viral burden. apart from these, initial studies has been demonstrated the efficacy of cmx001 for pre-exposure and post-exposure prophylaxis in mouse, rabbit, cynomolgus monkeys and human [1].
in vivo
Brincidofovir (BCV) (20 mg/kg; p.o.; on days 1, 3, 5, 7, 10, 14, 17, 21, and 24) extends survival in immune-deficient BALB/c nu/nu mice following lethal challenge with IHD-J-Luc VACV[3].
| Animal Model: | BALB/c nu/nu mice (infected with IHD-J-Luc VACV)[3] |
| Dosage: | 20 mg/kg |
| Administration: | P.o.; on days 1, 3, 5, 7, 10, 14, 17, 21, and 24 |
| Result: | On days 1, 3, and 5 maintained their weights initially but started to lose weight beginning on day 9 and succumbed between days 24 and 29 postchallenge. |
References
[1]lanier r1, trost l, tippin t, lampert b, robertson a, foster s, rose m, painter w, o'mahony r, almond m, painter g.development of cmx001 for the treatment of poxvirus infections. viruses. 2010 dec; 2(12):2740-2762.
CMX 001 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CMX 001 manufacturers
- Product
- Brincidofovir 444805-28-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98% HPLC
- Supply Ability
- 1kg
- Release date
- 2023-08-02
- Product
- Brincidofovir 444805-28-1
- Price
- US $2500.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-11-12