ChemicalBook > CAS DataBase List > CVT-12012
CVT-12012
- Product Name
- CVT-12012
- CAS No.
- 1018675-35-8
- Chemical Name
- CVT-12012
- Synonyms
- CS-2863;CVT-2012;CVT-12012;CVT-12012, 10 mM in DMSO;CVT 12012,Stearoyl-CoA Desaturase (SCD),inhibit,CVT12012,Inhibitor,CVT-12012;2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)phenyl]methylamino]quinoxalin-1-yl]ethyl]acetamide;2-Hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]acetamide;Acetamide, 2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]-;2-Hydroxy-N-(2-(3-methyl-2-oxo-7-(((3-(trifluoromethyl)phenyl)methyl)amino)-1,2-dihydroquinoxalin-1-yl)ethyl)acetamide
- CBNumber
- CB02627711
- Molecular Formula
- C21H21F3N4O3
- Formula Weight
- 434.41
- MOL File
- 1018675-35-8.mol
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CVT-12012 Property
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
- pka
- 13.29±0.10(Predicted)
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 27156
- Product name
- CVT-12012
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27156
- Product name
- CVT-12012
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27156
- Product name
- CVT-12012
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27156
- Product name
- CVT-12012
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-0003005
- Product name
- CVT-12012
- Purity
- 98.97%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
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CVT-12012 Chemical Properties,Usage,Production
Uses
CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively.
in vivo
In a rat PK study, CVT-12012 demonstrates good oral bioavailability (78%). It appears that the oral absorption of CVT-12012 is not affected by a significant Pgp efflux, which is expected based on Caco-2 assay result. The plasma clearance of CVT-12012 is high (88 mL/min/kg) with elimination half-life of approximately 1 h[1].
References
[1] Koltun DO, et al. Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4070-4. DOI:10.1016/j.bmcl.2009.06.017
[2] Atkinson KA, et al. N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1621-5. DOI:10.1016/j.bmcl.2011.01.113
CVT-12012 Preparation Products And Raw materials
Raw materials
Preparation Products
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CVT-12012 Suppliers
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- 021-52996696，15000506266 15000506266
- Fax
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- Country
- China
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