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PRT062607 (Hydrochloride)

Product Name
PRT062607 (Hydrochloride)
CAS No.
1370261-97-4
Chemical Name
PRT062607 (Hydrochloride)
Synonyms
CS-995;BIIB057 HCl;PRT-2607 HCl;PRT062607 HCL;P505-15 hydrochloride;PRT062607 (P505-15 HCL);PRT062607 (Hydrochloride);PRT062607 monohydrochloride;PRT062607 (P505-15) HCl ，S8032;PRT062607 (P505-15, BIIB057) HCl
CBNumber
CB02628293
Molecular Formula
C19H24ClN9O
Formula Weight
429.90656
MOL File
1370261-97-4.mol
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PRT062607 (Hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
≥21.5 mg/mL in DMSO; insoluble in EtOH; ≥83.2 mg/mL in H2O with gentle warming
form 
solid
color 
Light yellow to khaki
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A604640
Product name
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamideHydrochloride
Packaging
5mg
Price
$165
Updated
2021/12/16
TRC
Product number
A604640
Product name
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamideHydrochloride
Packaging
25mg
Price
$605
Updated
2021/12/16
AK Scientific
Product number
2672AH
Product name
PRT062607HCl
Packaging
50mg
Price
$652
Updated
2021/12/16
ChemScene
Product number
CS-1488
Product name
PRT062607Hydrochloride
Purity
98.06%
Packaging
5mg
Price
$142
Updated
2021/12/16
ChemScene
Product number
CS-1488
Product name
PRT062607Hydrochloride
Purity
98.06%
Packaging
50mg
Price
$576
Updated
2021/12/16
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PRT062607 (Hydrochloride) Chemical Properties,Usage,Production

Uses

PRT062607 (Hydrochloride)acts as a novel spleen tyrosine kinase (syk) inhibitors used in the treatment of leukemia.

in vivo

PRT062607 Hydrochloride produced dose-dependent anti-inflammatory activity in two rodent models of rheumatoid arthritis. PRT062607 Hydrochloride (15, 30 mg/kg; po; bid; 5 d) causes SYK inhibition in mice and prevents BCR-induced splenomegaly in mice[1].
PRT062607 Hydrochloride (15 mg/kg; po ; bid; 5 d) SYK inhibition in mice prevents Ramos tumor formation in mouse xenograft models[1].
PRT062607 Hydrochloride (10-20 mg/kg; po; bid, ) prevents BCR mediated splenomegaly and significantly inhibited NHL tumor growth in xenograft models[2].

Animal Model:anti-IgD Stimulated Mouse Inflammation Model[1]
Dosage:10 mg/kg, 15 mg/kg, 20 mg/kg
Administration:po; bid for 5 days
Result:Suppressed mouse B-cell activation following stimulation with this anti-IgD.
Animal Model:Ramos Tumor Xenograft Model in NOD/SCID mice[1]
Dosage:15 mg/kg, 30 mg/kg
Administration:po; bid; terminated when tumor weights began reaching approximately 1.5 mg, at which time tumors were excised and weighed.
Result:Protected mouse from Ramos tumor growth in vivo.

target

Syk

IC 50

Lck: 249 nM (IC50, [2]); PAK5: 166 nM (IC50, [2])

PRT062607 (Hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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PRT062607 (Hydrochloride) Suppliers

China 115 India 1 United Kingdom 1 United States 12 Global 129
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Jinan Trio PharmaTech Co., Ltd.
Tel
0531-88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
Shanghai Hope Chem Co., Ltd.，
Tel
+21-18501659228 18501659228
Fax
sales@hope-chem.com
Email
info@hope-chem.com
Country
China
ProdList
474
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52

1370261-97-4, PRT062607 (Hydrochloride)Related Search:

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  • PRT062607 (Hydrochloride)
  • PRT062607 (P505-15, BIIB057) HCl
  • P505-15 hydrochloride
  • CS-995
  • BIIB057 HCl
  • 4-((4-(2H-1,2,3-Triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide hydrochloride
  • P505-15; PRT2607; PRT-2607; PRT 2607; PRT-062607; PRT 062607; P505-15; BIIB057
  • 2-[[(1R,2S)-2-AMinocyclohexyl]aMino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]aMino]-5-pyriMidinecarboxaMide Hydrochloride
  • PRT062607 (P505-15 HCL)
  • PRT062607 HCL
  • 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide hydrochloride (1:1)
  • PRT-2607 HCl
  • P505-15 HCl salt, PRT062607 HCl salt,PRT-2607 HCl salt, BIIB-057 HCl salt
  • P505-15, BIIB057 HCl, PRT062607(HCL)
  • PRT062607 (P505-15, BIIB057) hydrochloride
  • 4-((4-(2H-1,2,3-Triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-ca
  • 5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-, hydrochloride (1:1)
  • 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide hydrochloride (1:1) PRT062607 (P505-15, BIIB057) HCl
  • PRT062607 (Hydrochloride) USP/EP/BP
  • 4-((3-(2H-1,2,3-Triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide hydrochloride
  • PRT062607 hydrochloride, 10 mM in DMSO
  • PRT062607 monohydrochloride
  • PRT062607 (P505-15) HCl ，S8032
  • 1370261-97-4
  • C19H23N9OHCl
  • C19H24ClN9O
  • Inhibitors
  • Pharmaceuticals, Intermediates & Fine Chemicals