R406

Product Name: R406
CAS No.: 841290-81-1
Chemical Name: R406
Synonyms: Tamatinib;CS-735;R406, >=98%;R406 tosilate;R406 besylate;R406 supplier;Tamatinib besylate;R406(benzenesulfonate);R406 benzenesulfonic acid;Tamatinib besylate (R406)
CBNumber: CB42546436
Molecular Formula: C28H29FN6O8S
Formula Weight: 628.6286632
MOL File: 841290-81-1.mol

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R406 Property

storage temp.: Store at -20°C
solubility: ≥31.45 mg/mL in DMSO; insoluble in H2O; ≥14.95 mg/mL in EtOH with ultrasonic
form: solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: R060000
Product name: R406
Packaging: 2mg
Price: $110
Updated: 2021/12/16

TRC

Product number: R060000
Product name: R406
Packaging: 10mg
Price: $250
Updated: 2021/12/16

TRC

Product number: R060000
Product name: R406
Packaging: 50mg
Price: $675
Updated: 2021/12/16

ChemScene

Product number: CS-0229
Product name: R406
Purity: 96.67%
Packaging: 50mg
Price: $720
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FR103901
Product name: R 406
Packaging: 50mg
Price: $472.5
Updated: 2021/12/16

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R406 Chemical Properties,Usage,Production

Uses

R406 is a potent Syk inhibitor which affects Dectin-1-mediated signalling in mammilian cells. R406 thus acts an anti-fungal agent. Also a potential anti-leukemia agent, through modulation of sphingosine-1 phosphate receptor 1 (S1PR1).

Biological Activity

r406 is a potent syk inhibitorspleen tyrosine kinase (syk) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. it transmits signals from a variety of cell surface receptors including cd74, fc receptor and integrins. it is crucial for adaptive immune response, and also very important for cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. [1]functional abnormality of syk has been implicated in several blood malignancies. constitutively active syk can transform b cells. syk inhibition can be beneficial for patients with blood cancers and autoimmune diseases.r406 is a potent inhibitor of ige and igg mediated fc receptor activation with ec50 for degranulation of 56-64 nm. [2] r406 targets syk and inhibits phosphorylation of syk substrates by binding to its atp binding pocket and competing with atp. r406 strongly inhibits syk kinase activity with an ic50 of 41 nm.r406 induces apoptosis in diffuse large b-cell lymphoma cell lines. it blocks b cell receptor signaling through inhibiton of syk autophosphorylation of y525/y526 and syk-dependent phosphorylation of the b-cell linker protein. [3]r406 can be administrated orally.

target

Syk

References

[1]mocsai a, ruland j, tybulewicz vl. the syk tyrosine kinase: a crucial player in diverse biological functions. nat rev immunol 2010. 10(6): 387-402.
[2]braselmann s, taylor v, zhao h, et al. r406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. j pharmacol exp ther 2006. 319(3): 998-1008.
[3]chen l, monti s, juszczynski p, et al. syk-dependent tonic b-cell receptor signaling is a rational treatment target in diffuse large b-cell lymphoma. blood 2008. 111(4): 2230*2237.

R406 Preparation Products And Raw materials

Raw materials

Preparation Products

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R406 Suppliers

China 77 India 2 United Kingdom 1 United States 15 Global 95

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4648
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9452
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1494
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9901
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

Shanghai MOF Chemical Tech Limited

Tel: 13661494087 18964793018
Fax: 86-021-51821718 QQ：2427604606
Email: sales@mof-chemicals.com
Country: China
ProdList: 293
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Wulechem Co., Ltd.

Tel: 13761914825
Fax: 02131135716
Email: wulesian@wulechem.com
Country: China
ProdList: 300
Advantage: 58

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View Lastest Price from R406 manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: R406 besylate 841290-81-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-09

841290-81-1, R406Related Search:

R-406 1,9-Pyrazoloanthrone Alisertib (MLN8237) Dasatinib Ibrutinib PRT062607 (Hydrochloride) PLX4032

6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one benzenesulfonate

Tamatinib

CS-735

R406(benzenesulfonate)

6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one benzenesulfonate

R406, >=98%

R406 tosilate

6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2

R406 supplier

benzenesulfonic acid,6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

R406 besylate

R406 benzenesulfonic acid

2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one,6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-, monobenzenesulfonate

Tamatinib besylate (R406)

Spleen tyrosine kinase,Fms like tyrosine kinase 3,Syk,FLT3,R406,inhibit,R 406,CD135,Inhibitor,Apoptosis,Cluster of differentiation antigen 135,R-406

Tamatinib besylate

841290-81-1

C22H23FN6O5C6H6O3S

C28H29FN6O8S

Inhibitors