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SCH1473759 (HCl salt)

Product Name
SCH1473759 (HCl salt)
CAS No.
1094067-13-6
Chemical Name
SCH1473759 (HCl salt)
Synonyms
SCH-1473759 HCl;SCH1473759 (HCl salt);SCH-1473759 hydrochloride;SCH-1473759 hydrochloride /1094067-13-6;Aurora Kinase,inhibit,SCH1473759,Inhibitor,SCH 1473759,SCH1473759 hydrochloride,SCH 1473759 hydrochloride,SCH-1473759
CBNumber
CB02628389
Molecular Formula
C20H27ClN8OS
Formula Weight
463
MOL File
1094067-13-6.mol
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SCH1473759 (HCl salt) Property

storage temp. 
Store at -20°C
solubility 
DMSO: 70 mg/mL (151.19 mM)
form 
Solid
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3477
Product name
SCH-1473759hydrochloride
Purity
99.67%
Packaging
2mg
Price
$144
Updated
2021/12/16
ChemScene
Product number
CS-3477
Product name
SCH-1473759hydrochloride
Purity
99.67%
Packaging
5mg
Price
$264
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611479
Product name
SCH-1473759 hydrochloride
Packaging
5mg
Price
$368.9
Updated
2021/12/16
ChemScene
Product number
CS-3477
Product name
SCH-1473759hydrochloride
Purity
99.67%
Packaging
10mg
Price
$384
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000833
Product name
SCH-1473759 HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$500.65
Updated
2021/12/16
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SCH1473759 (HCl salt) Chemical Properties,Usage,Production

Uses

SCH-1473759 hydrochloride is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.

in vivo

SCH-1473759 at a low dose of 5 mg/kg (ip, bid) is well-tolerated in a continuous dosing schedule and shows 50% tumor growth inhibition(TGI) on day 16. A higher dose of 10mg/kg(ip, bid) is well-tolerated in an intermittent schedule (5 days on, 5 days off) and gave 69% TGI on day 16. SCH-1473759 shows good exposure in all species with the clearance being high in rodents and moderate in dog and monkey. The half-life is also moderate, but the tissue distribution is high[1]. SCH 1473759 dose- and schedule-dependent anti-tumor activity in four human tumor xenograft models. Further, the efficacy is enhanced in combination with taxanes and found to be most efficacious when SCH 1473759 is dosed 12-h post-taxane treatment[2].

IC 50

Aurora A: 4 nM (IC50); Aurora B: 13 nM (IC50)

References

[1] Yu T, et al. Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8. DOI:10.1021/ml100063w
[2] Basso AD, et al. SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33. DOI:10.1007/s00280-011-1568-1

SCH1473759 (HCl salt) Preparation Products And Raw materials

Raw materials

Preparation Products

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SCH1473759 (HCl salt) Suppliers

China 27 United States 5 Global 32
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
MedChemExpress
Tel
--
Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1094067-13-6, SCH1473759 (HCl salt)Related Search:


  • SCH1473759 (HCl salt)
  • SCH-1473759 hydrochloride
  • SCH-1473759 HCl
  • Aurora Kinase,inhibit,SCH1473759,Inhibitor,SCH 1473759,SCH1473759 hydrochloride,SCH 1473759 hydrochloride,SCH-1473759
  • SCH-1473759 hydrochloride /1094067-13-6
  • 1094067-13-6