2-Chloro-4-MethoxypyriMidin-5-aMine
- Product Name
- 2-Chloro-4-MethoxypyriMidin-5-aMine
- CAS No.
- 96833-41-9
- Chemical Name
- 2-Chloro-4-MethoxypyriMidin-5-aMine
- Synonyms
- 2-CHLORO-4-METHOXYPYRIMIDIN-5-AMIN;2-Chloro-4-methoxy-5-pyrimidinamine;2-Chloro-4-MethoxypyriMidin-5-aMine;2-chloro-4-methoxy-5-Aminopyrimidine;5-Amino-2-chloro-4-methoxypyrimidine;5-Pyrimidinamine, 2-chloro-4-methoxy-;2-Chloro-4-methoxypyrimidin-5-ylamine;2-chloro-4-methoxypyrimidine-5-ylamine
- CBNumber
- CB02638610
- Molecular Formula
- C5H6ClN3O
- Formula Weight
- 159.57
- MOL File
- 96833-41-9.mol
2-Chloro-4-MethoxypyriMidin-5-aMine Property
- Boiling point:
- 349.6±22.0 °C(Predicted)
- Density
- 1.398±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.36±0.29(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5514AJ
- Product name
- 2-Chloro-4-methoxypyrimidin-5-amine
- Packaging
- 5g
- Price
- $558
- Updated
- 2021/12/16
- Product number
- 5514AJ
- Product name
- 2-Chloro-4-methoxypyrimidin-5-amine
- Packaging
- 25g
- Price
- $2576
- Updated
- 2021/12/16
- Product number
- 96833419
- Product name
- 5-Amino-2-chloro-4-methoxypyrimidine
- Packaging
- 5g
- Price
- $570.93
- Updated
- 2021/12/16
- Product number
- CM256026
- Product name
- 2-Chloro-4-methoxypyrimidin-5-amine
- Purity
- 97%
- Packaging
- 10g
- Price
- $664
- Updated
- 2021/12/16
- Product number
- AZ0001-0591
- Product name
- 2-Chloro-4-methoxypyrimidin-5-amine
- Purity
- 98
- Packaging
- 5G
- Price
- $790
- Updated
- 2021/12/16
2-Chloro-4-MethoxypyriMidin-5-aMine Chemical Properties,Usage,Production
Synthesis
5177-27-5
124-41-4
96833-41-9
General procedure for the preparation of 2-chloro-4-methoxypyrimidin-5-amine: sodium methanolate (0.5 M solution in methanol, 3.7 mL, 1.829 mmol) was slowly added to a solution of 2,4-dichloropyrimidin-5-amine (0.2 g, 1.220 mmol) in methanol (2.5 mL). The reaction mixture was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate and quenched with deionized water. The organic and aqueous layers were separated and the aqueous layer was further extracted with ethyl acetate. All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the title compound 2-chloro-4-methoxypyrimidin-5-amine as a brown solid (177 mg, 91% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 3.93 (s, 3H), 5.31 (br s, 2H), 7.73 (s, 1H).LC-MS analysis (Method B, ESI positive ion mode) showed a retention time t R of 1.6 min and a molecular ion peak m/z of 160 [M + H]+ .
References
[1] Patent: US2013/345181, 2013, A1. Location in patent: Paragraph 0785
[2] Patent: WO2014/184234, 2014, A1. Location in patent: Page/Page column 71; 72
[3] Patent: WO2014/191632, 2014, A1. Location in patent: Page/Page column 56
2-Chloro-4-MethoxypyriMidin-5-aMine Preparation Products And Raw materials
Raw materials
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