ChemicalBook > CAS DataBase List > (1R,3S)-3-AMinocyclopentanol hydrochloride

(1R,3S)-3-AMinocyclopentanol hydrochloride

Product Name
(1R,3S)-3-AMinocyclopentanol hydrochloride
CAS No.
1279032-31-3
Chemical Name
(1R,3S)-3-AMinocyclopentanol hydrochloride
Synonyms
Intermediate of Bictegravir;(1R,3S)-3-aminocyclopentanolHCL;1R.3S)-3- Aminocyclopentaro1hydroch1oj de;Cyclopentanol, 3-amino-, hydrochloride (1:1), (1R,3S)-;1R,3S)-3-Aminocyclopentanol hydrochloride(Bictegravir);(1R,3S)-3-AMinocyclopentanol hydrochloride ISO 9001：2015 REACH
CBNumber
CB02640798
Molecular Formula
C5H12ClNO
Formula Weight
137.61
MOL File
1279032-31-3.mol
More
Less

(1R,3S)-3-AMinocyclopentanol hydrochloride Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Pale Yellow
InChI
InChI=1/C5H11NO.ClH/c6-4-1-2-5(7)3-4;/h4-5,7H,1-3,6H2;1H/t4-,5+;/s3
InChIKey
SGKRJNWIEGYWGE-SRJSDOSHNA-N
SMILES
N[C@H]1CC[C@@H](O)C1.Cl |&1:1,4,r|
CAS DataBase Reference
1279032-31-3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
A596540
Product name
(1R,3S)-3-AminocyclopentanolHydrochloride
Packaging
25mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-B1526
Product name
(1R,3S)-3-Aminocyclopentanolhydrochloride
Purity
≥98.0%
Packaging
250mg
Price
$58
Updated
2021/12/16
ChemScene
Product number
CS-B1526
Product name
(1R,3S)-3-Aminocyclopentanolhydrochloride
Purity
≥98.0%
Packaging
1g
Price
$145
Updated
2021/12/16
ChemScene
Product number
CS-B1526
Product name
(1R,3S)-3-Aminocyclopentanolhydrochloride
Purity
≥98.0%
Packaging
5g
Price
$465
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
35444
Product name
(1R,3S)-3-AminocyclopentanolHCl
Purity
95+%
Packaging
100mg
Price
$545
Updated
2021/12/16
More
Less

(1R,3S)-3-AMinocyclopentanol hydrochloride Chemical Properties,Usage,Production

Description

(1R,3S)-3-aminocyclopentanol hydrochloride is an alcohol derivative and can be used as a pharmaceutical intermediate.

Uses

(1R,3S)-3-aminocyclopentanol hydrochloride is used in the preparation of 6-aminopyridine-3-thiazole as a method for treating or improving rheumatoid arthritis or psoriasis.

Application

(1R,3S)-3-aminocyclopentanol hydrochloride is an intermediate in organic synthesis and pharmaceutical intermediate, which can be used in laboratory research and development process and chemical production process.

Synthesis

167465-99-8

1279032-31-3

Under nitrogen protection, 82 g of isopropanol was added to the reaction flask. Stirring was turned on, the reaction temperature was controlled at 5 °C, and 93.4 g of pivaloyl chloride was slowly added dropwise. After the dropwise addition, the reaction temperature was adjusted to 25 °C and the esterification reaction was carried out for 30 min. Subsequently, a solution prepared from 52 g of Compound III dissolved in 53 g of isopropanol was added dropwise to the reaction system. After completion of the dropwise addition, the deprotection reaction was carried out at room temperature for 12 h. The reaction process was monitored by GC. At the end of the reaction, the temperature of the reaction system was controlled at 0 °C and stirring was continued for 1 h to ensure complete precipitation of solids. Filtration was carried out under nitrogen protection and the resulting filter cake was washed with isopropanol at 5 °C until the washings were colorless. Next, the filter cake was washed with 40 g of acetone, stirred and heated to 50 °C and maintained for 2 hours. After completion of the reaction, the product was cooled to 0 °C and filtered under nitrogen protection, and the filter cake was washed with acetone at 5 °C until no droplets fell. Finally, the product was dried under vacuum at 40 °C for 12 h to give 25.4 g of (1R,3S)-3-aminocyclopentanol hydrochloride, which was 99.75% pure by GC, with less than 0.01% optical isomer impurities, and 69.8% overall yield based on Compound I.

References

[1] Patent: CN108774145, 2018, A. Location in patent: Paragraph 0080; 0083; 0085; 0088; 0089; 0092; 0093; 0096
[2] Patent: CN108774145, 2018, A. Location in patent: Paragraph 0104

(1R,3S)-3-AMinocyclopentanol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(1R,3S)-3-AMinocyclopentanol hydrochloride Suppliers

China 174 India 3 United States 5 Global 182
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
21193
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
More
Less

View Lastest Price from (1R,3S)-3-AMinocyclopentanol hydrochloride manufacturers

Changzhou Rokechem Technology Co., Ltd.
Product
(1R,3S)-3-AMinocyclopentanol hydrochloride 1279032-31-3
Price
US $0.00-0.00/G
Min. Order
1G
Purity
≥98%
Supply Ability
1-10000g
Release date
2023-04-17
TAIZHOU DKD CHEMICAL CO., LTD.
Product
(1R,3S)-3-AMINOCYCLOPENTANOL HYDROCHLORIDE 1279032-31-3
Price
US $0.00/kg
Min. Order
25kg
Purity
99%
Supply Ability
20 tons
Release date
2022-11-02
Longyan Tianhua Biological Technology Co., Ltd
Product
(1R,3S)-3-AMinocyclopentanol hydrochloride 1279032-31-3
Price
US $65.00/KG
Min. Order
1KG
Purity
99
Supply Ability
1000KG
Release date
2020-11-17

1279032-31-3, (1R,3S)-3-AMinocyclopentanol hydrochlorideRelated Search:

Trimethylamine hydrochloride (1R,3S)-3-Aminocyclopentanol Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)

  • (1R,3S)-3-aminocyclopentanolHCL
  • Intermediate of Bictegravir
  • 1R,3S)-3-Aminocyclopentanol hydrochloride(Bictegravir)
  • Cyclopentanol, 3-amino-, hydrochloride (1:1), (1R,3S)-
  • (1R,3S)-3-AMinocyclopentanol hydrochloride ISO 9001：2015 REACH
  • 1R.3S)-3- Aminocyclopentaro1hydroch1oj de
  • 1279032-31-3
  • 1279032-31-3