ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE

Product Name: ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE
CAS No.: 1227934-69-1
Chemical Name: ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE
Synonyms: Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylat;ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE;ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)-1,3-OXAZOLE-5-CARBOXYLATE;5-Oxazolecarboxylic acid, 2-bromo-4-(trifluoromethyl)-, ethyl ester
CBNumber: CB02646932
Molecular Formula: C7H5BrF3NO3
Formula Weight: 288.02
MOL File: 1227934-69-1.mol

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ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE Property

Boiling point:: 297.5±50.0 °C(Predicted)
Density: 1.698±0.06 g/cm3(Predicted)
pka: -6.06±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E938228
Product name: Ethyl2-Bromo-4-(trifluoromethyl)oxazole-5-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 9360BB
Product name: Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate
Packaging: 250mg
Price: $281
Updated: 2021/12/16

AK Scientific

Product number: 9360BB
Product name: Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate
Packaging: 1g
Price: $616
Updated: 2021/12/16

Crysdot

Product number: CD11321283
Product name: Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate
Purity: 95+%
Packaging: 100mg
Price: $103
Updated: 2021/12/16

Crysdot

Product number: CD11321283
Product name: Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $164
Updated: 2021/12/16

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ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

135026-17-4

1227934-69-1

Step 2: Ethyl 2-amino-4-(trifluoromethyl)oxazole-5-carboxylate (A-1) (9.8 g) was suspended in acetonitrile (100 mL), and copper (II) bromide (11.8 g) and tert-butylnitrite (13.8 mL) were slowly added sequentially at 0 °C. The reaction mixture was slowly warmed from 0 °C to room temperature under nitrogen protection and stirred at this temperature for 4 hours. Upon completion of the reaction, the mixture was concentrated. The concentrated residue was suspended in EtOAc (200 mL), washed sequentially with 1N HCl (3 x 100 mL) and brine (1 x 100 mL), and the organic phase was dried over Na2SO4, filtered and concentrated. The crude product was purified by fast column chromatography (eluent: EtOAc/hexane) to afford ethyl 2-bromo-4-trifluoromethyl oxazole-5-carboxylate (A-2) as a colorless liquid (9.18 g, 73% yield).LCMS (ESI) [M + 1]+ 288.2.

References

[1] Patent: WO2010/59606, 2010, A2. Location in patent: Page/Page column 159
[2] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00321
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 23, p. 6410 - 6414

ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE Suppliers

China 18 India 1 United States 2 Global 21

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1227934-69-1, ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATERelated Search:

Ethyl 2-bromo-3-hydroxy-6-methylisonicotinate Ethyl 2-chloro-5-Methylnicotinate Ethyl 2-amino-6-(trifluoromethyl)nicotinate 2-CHLORO-3-METHYLPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER ethyl 2-bromo-5-chloroisonicotinate Ethyl 2-amino-5-fluoronicotinate 2-Chloro-5-methylpyridine-4-carboxylic acid ethyl ester

ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE

Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylat

ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)-1,3-OXAZOLE-5-CARBOXYLATE

5-Oxazolecarboxylic acid, 2-bromo-4-(trifluoromethyl)-, ethyl ester

1227934-69-1

C7H5BrF3NO3