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Tivozanib

Product Name
Tivozanib
CAS No.
682745-41-1
Chemical Name
Tivozanib
Synonyms
Tivozanib hydrochloride;Tivozanib hydrochloride hydrate;Tivozanib Hydrochloride Monohydrate;1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-urea monohydrochloride monohydrate
CBNumber
CB02651167
Molecular Formula
C22H22Cl2N4O6
Formula Weight
509.34
MOL File
682745-41-1.mol
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Tivozanib Property

storage temp. 
4°C, away from moisture and light
solubility 
DMSO : 250 mg/mL (490.83 mM; Need ultrasonic)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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Tivozanib Chemical Properties,Usage,Production

Uses

Tivozanib also known as AV-951 is an orally bioavailable potent VEGFR-1, 2 and 3, c-Kit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM, respectively.

in vivo

Tivozanib hydrochloride hydrate (0.04-1 mg/kg, po for 14 days) exhibits antitumor efficacy against breast, colon, hepatic, lung, ovarian, pancreatic, and prostate cancer in athymic mice model[1].
Tivozanib hydrochloride hydrate (0.2-1 mg/kg, po for 21 days) reversibly suppresses vascular permeability and angiogenesis in Calu-6 tumor bearing rats model[1].
Tivozanib hydrochloride hydrate (5 mg/kg, po, single dose) reveals a AUCinf of 44.5 μg·h/mL, Cmax of 2823 ng/mL in athymic mice model[1].

Animal Model:Calu-6 tumor bearing athymic mice model[1]
Dosage:0.04-1 mg/kg/day
Administration:p.o., for 14-21 days
Result: Inhibited tumor growth, angiogenesis and vascular permeability.

IC 50

VEGFR-2: 6.5 nM (IC50); VEGFR-3: 15 nM (IC50); VEGFR-1: 30 nM (IC50)

Tivozanib Preparation Products And Raw materials

Raw materials

Preparation Products

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Tivozanib Suppliers

China 28 United States 1 Global 29
Jinan Trio PharmaTech Co., Ltd.
Tel
0531-88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com
Country
China
ProdList
1856
Advantage
62
Shanghai Hope Chem Co., Ltd.，
Tel
+21-18501659228 18501659228
Fax
sales@hope-chem.com
Email
info@hope-chem.com
Country
China
ProdList
474
Advantage
55
Shanghai AECOM Biotechnology Co. , Ltd.
Tel
021-021-20956531 18116226605
Fax
021-20956532
Email
sui@neosunpharm.com
Country
China
ProdList
349
Advantage
55
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9273
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2988
Advantage
58
WuHu Linze pharmaceutical Co.,Ltd.
Tel
18356571950
Fax
-
Email
2030235803@qq.com
Country
China
ProdList
94
Advantage
58
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View Lastest Price from Tivozanib manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Tivozanib Hydrochloride Hydrate 682745-41-1
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-07-24
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Tivozanib Hydrochloride 682745-41-1
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-12-31

682745-41-1, TivozanibRelated Search:


  • 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
  • N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-urea monohydrochloride monohydrate
  • Tivozanib hydrochloride
  • Tivozanib hydrochloride hydrate
  • Tivozanib Hydrochloride Monohydrate
  • 682745-41-1
  • C22H22Cl2N4O6