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Tivozanib

Product Name
Tivozanib
CAS No.
682745-41-1
Chemical Name
Tivozanib
Synonyms
Tivozanib hydrochloride;Tivozanib hydrochloride hydrate;Tivozanib Hydrochloride Monohydrate;1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-urea monohydrochloride monohydrate
CBNumber
CB02651167
Molecular Formula
C22H22Cl2N4O6
Formula Weight
509.34
MOL File
682745-41-1.mol
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Tivozanib Property

storage temp. 
4°C, away from moisture and light
solubility 
DMSO : 250 mg/mL (490.83 mM; Need ultrasonic)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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Tivozanib Chemical Properties,Usage,Production

Uses

Tivozanib also known as AV-951 is an orally bioavailable potent VEGFR-1, 2 and 3, c-Kit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM, respectively.

in vivo

Tivozanib hydrochloride hydrate (0.04-1 mg/kg, po for 14 days) exhibits antitumor efficacy against breast, colon, hepatic, lung, ovarian, pancreatic, and prostate cancer in athymic mice model[1].
Tivozanib hydrochloride hydrate (0.2-1 mg/kg, po for 21 days) reversibly suppresses vascular permeability and angiogenesis in Calu-6 tumor bearing rats model[1].
Tivozanib hydrochloride hydrate (5 mg/kg, po, single dose) reveals a AUCinf of 44.5 μg·h/mL, Cmax of 2823 ng/mL in athymic mice model[1].

Animal Model:Calu-6 tumor bearing athymic mice model[1]
Dosage:0.04-1 mg/kg/day
Administration:p.o., for 14-21 days
Result: Inhibited tumor growth, angiogenesis and vascular permeability.

IC 50

VEGFR-2: 6.5 nM (IC50); VEGFR-3: 15 nM (IC50); VEGFR-1: 30 nM (IC50)

Tivozanib Preparation Products And Raw materials

Raw materials

Preparation Products

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Tivozanib Suppliers

China 28 United States 1 Global 29
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
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View Lastest Price from Tivozanib manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Tivozanib Hydrochloride Hydrate 682745-41-1
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-07-24
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Tivozanib Hydrochloride 682745-41-1
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-12-31

682745-41-1, TivozanibRelated Search:


  • 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
  • N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-urea monohydrochloride monohydrate
  • Tivozanib hydrochloride
  • Tivozanib hydrochloride hydrate
  • Tivozanib Hydrochloride Monohydrate
  • 682745-41-1
  • C22H22Cl2N4O6