AVL-292

ChemicalBook > CAS DataBase List > AVL-292

Product Name: AVL-292
CAS No.: 1202757-89-8
Chemical Name: AVL-292
Synonyms: CS-733;CC-292;LMK-435;AVL-292;Spebrutinib;AVL-292 >=98%;CC-292,LMK-435;CC-292 (AVL-292);AVL 292 - CC 292;AVL-292 USP/EP/BP
CBNumber: CB02655392
Molecular Formula: C22H22FN5O3
Formula Weight: 423.44
MOL File: 1202757-89-8.mol

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AVL-292 Property

Density: 1.322±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥21.15 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 13.22±0.70(Predicted)
color: White to khaki
CAS DataBase Reference: 1202757-89-8

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17993
Product name: AVL-292
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17993
Product name: AVL-292
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 17993
Product name: AVL-292
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 17993
Product name: AVL-292
Purity: ≥98%
Packaging: 50mg
Price: $957
Updated: 2024/03/01

TRC

Product number: A794715
Product name: AVL-292
Packaging: 100mg
Price: $610
Updated: 2021/12/16

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AVL-292 Chemical Properties,Usage,Production

Uses

Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).[Cayman Chemical]

target

Btk

AVL-292 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AVL-292 manufacturers

Zhejiang J&C Biological Technology Co.,Limited

Product: AVL-292 1202757-89-8
Price: US $0.00/gram
Min. Order: 1gram
Purity: 99%
Supply Ability: 10kg
Release date: 2022-02-17

Career Henan Chemical Co

Product: AVL-292 1202757-89-8
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

1202757-89-8, AVL-292Related Search:

Dabrafenib CAL-101 CO-1686 Ibrutinib AZD-9291 CNX-774

AVL-292

LMK-435

N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide

2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-

CC-292 (AVL-292)

CC-292,LMK-435

N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide AVL292

CC-292

Spebrutinib

N-(3-((5-fluoroethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

CS-733

N-(3-((5-fluoroethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide (AVL-292)

CC-292; AVL292; AVL-292; AVL 292

AVL 292 - CC 292

CC-292;AVL292;AVL-292;AVL 292;SPEBRUTINIB

AVL-292 (Spebrutinib)

AVL-292 >=98%

N-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

Spebrutinib (AVL-292)

Spebrutinib (CC-292, AVL-292)

N-{3-[(5-Fluoro-2-{[4-(2-methoxyethoxy)phenyl]amino}pyrimidin-4-yl)amino]phenyl}prop-2-enamide

AVL-292 USP/EP/BP

Spebrutinib (CC292

7-Epoxytropine hydrochloride

Spebrutinib, 10 mM in DMSO

1202757-89-8

Inhibitors