CNX-774

Product Name: CNX-774
CAS No.: 1202759-32-7
Chemical Name: CNX-774
Synonyms: CS-946;CNX-77;CNX-774;CNX-774(97 %);CNX774; CNX 774;CNX-774 USP/EP/BP;4-(4-((4-(acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide;4-(4-((4-((3-Acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamid;4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide;4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide
CBNumber: CB02666837
Molecular Formula: C26H22FN7O3
Formula Weight: 499.5
MOL File: 1202759-32-7.mol

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CNX-774 Property

Density: 1.383±0.06 g/cm3(Predicted)
storage temp.: Store at -20° C
solubility: Soluble in DMSO
form: Powder
pka: 13.22±0.70(Predicted)
color: Light yellow to yellow
CAS DataBase Reference: 1202759-32-7

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21475
Product name: CNX-774
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 21475
Product name: CNX-774
Purity: ≥98%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 21475
Product name: CNX-774
Purity: ≥98%
Packaging: 10mg
Price: $223
Updated: 2024/03/01

Cayman Chemical

Product number: 21475
Product name: CNX-774
Purity: ≥98%
Packaging: 25mg
Price: $469
Updated: 2024/03/01

TRC

Product number: C600000
Product name: CNX-774
Packaging: 5mg
Price: $120
Updated: 2021/12/16

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CNX-774 Chemical Properties,Usage,Production

Uses

CNX-774 is an irreversible, orally active, and highly selective inhibitor of Bruton’s tyrosine kinase (BTK) and can be used for the treatment of rheumatoid arthritis (RA).

Biological Activity

cnx-774 is an orally active and selective inhibitor of btk with ic50 value of <1 nm.bruton’s tyrosine kinase (btk) is an important enzyme in the b-cell antigen receptor (bcr) signaling pathway and also plays an important role in mast cell activation and b cell maturation.cnx-774 is an orally active, irreversible and selective btk inhibitor with ic50 value of <1 nm. cnx-774 formed covalent bond with the cys481 residue within the atp binding site of btk. in cellular assays, cnx-774 inhibited btk with ic50 values of 1-10 nm [1].

References

[1]. akinleye a, chen y, mukhi n, et al. ibrutinib and novel btk inhibitors in clinical development. j hematol oncol, 2013, 6: 59.

CNX-774 Preparation Products And Raw materials

Raw materials

Preparation Products

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CNX-774 Suppliers

China 102 India 2 United States 13 Global 117

Shanghai Boyle Chemical Co., Ltd.

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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
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MedChemexpress LLC

Tel: 021-58955995
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Email: sales@medchemexpress.cn
Country: United States
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AdooQ BioScience, LLC

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Fax: +1 (866) 333-9607
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Shanghai YuLue Chemical Co., Ltd.

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Email: lzz841106@aliyun.com
Country: China
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AdooQ Bioscience CHINA

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Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
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Credit Asia Chemical Co., Ltd.

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Country: China
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LETOPHARM LIMITED

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Shanghai Lollane Biological Technology Co.,Ltd.

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Fax: +86-21-52996696
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Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
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ProdList: 1005
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View Lastest Price from CNX-774 manufacturers

Career Henan Chemical Co

Product: CNX-774 1202759-32-7
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

1202759-32-7, CNX-774Related Search:

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CNX-774

4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide

4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide

4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide CNX-774

4-(4-((4-((3-Acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamid

2-Pyridinecarboxamide, 4-[4-[[5-fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-

4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide

CNX774; CNX 774

4-(4-((4-(acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide

CS-946

CNX-774(97 %)

CNX-774 USP/EP/BP

CNX-77

1202759-32-7

C26H22FN7O3

Inhibitors

API