ChemicalBook > CAS DataBase List > AVL-292
AVL-292
- Product Name
- AVL-292
- CAS No.
- 1202757-89-8
- Chemical Name
- AVL-292
- Synonyms
- CS-733;CC-292;LMK-435;AVL-292;Spebrutinib;AVL-292 >=98%;CC-292,LMK-435;CC-292 (AVL-292);AVL 292 - CC 292;AVL-292 USP/EP/BP
- CBNumber
- CB02655392
- Molecular Formula
- C22H22FN5O3
- Formula Weight
- 423.44
- MOL File
- 1202757-89-8.mol
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AVL-292 Property
- Density
- 1.322±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥21.15 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic
- form
- solid
- pka
- 13.22±0.70(Predicted)
- CAS DataBase Reference
- 1202757-89-8
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 17993
- Product name
- AVL-292
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17993
- Product name
- AVL-292
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17993
- Product name
- AVL-292
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $341
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17993
- Product name
- AVL-292
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $957
- Updated
- 2024/03/01
TRC
- Product number
- A794715
- Product name
- AVL-292
- Packaging
- 100mg
- Price
- $610
- Updated
- 2021/12/16
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AVL-292 Chemical Properties,Usage,Production
Uses
Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).[Cayman Chemical]
target
Btk
AVL-292 Preparation Products And Raw materials
Raw materials
Preparation Products
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AVL-292 Suppliers
- Tel
- 15053191807
- Fax
- -
- sales_sanzhi@163.com
- Country
- China
- ProdList
- 286
- Advantage
- 55
- Tel
- 021-13816613772 13816613772
- Fax
- QQ: 12922499
- huahero21@sina.com
- Country
- China
- ProdList
- 357
- Advantage
- 55
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2923
- Advantage
- 55
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- 021-54306202 13764082696;
- info@hanhongsci.com
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 21-021-64968085,64968086-5815,5812 13918693646
- Fax
- +86 21 64968087
- bd@rainbowpharma.cn
- Country
- China
- ProdList
- 946
- Advantage
- 65
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4647
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9439
- Advantage
- 58
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
- Fax
- +86-27-87599188
- Country
- China
- ProdList
- 1494
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
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View Lastest Price from AVL-292 manufacturers
Zhejiang J&C Biological Technology Co.,Limited
- Product
- AVL-292 1202757-89-8
- Price
- US $0.00/gram
- Min. Order
- 1gram
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2022-02-17
Career Henan Chemical Co
- Product
- AVL-292 1202757-89-8
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24