ChemicalBook > CAS DataBase List > CNX-774

CNX-774

Product Name
CNX-774
CAS No.
1202759-32-7
Chemical Name
CNX-774
Synonyms
CS-946;CNX-77;CNX-774;CNX-774(97 %);CNX774; CNX 774;CNX-774 USP/EP/BP;CNX-774, 10 mM in DMSO;4-(4-((4-(acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide;4-(4-((4-((3-Acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamid;4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
CBNumber
CB02666837
Molecular Formula
C26H22FN7O3
Formula Weight
499.5
MOL File
1202759-32-7.mol
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CNX-774 Property

Density 
1.383±0.06 g/cm3(Predicted)
storage temp. 
Store at -20° C
solubility 
Soluble in DMSO
form 
Powder
pka
13.22±0.70(Predicted)
color 
Light yellow to yellow
CAS DataBase Reference
1202759-32-7
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21475
Product name
CNX-774
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
21475
Product name
CNX-774
Purity
≥98%
Packaging
5mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
21475
Product name
CNX-774
Purity
≥98%
Packaging
10mg
Price
$223
Updated
2024/03/01
Cayman Chemical
Product number
21475
Product name
CNX-774
Purity
≥98%
Packaging
25mg
Price
$469
Updated
2024/03/01
TRC
Product number
C600000
Product name
CNX-774
Packaging
5mg
Price
$120
Updated
2021/12/16
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CNX-774 Chemical Properties,Usage,Production

Uses

CNX-774 is an irreversible, orally active, and highly selective inhibitor of Bruton’s tyrosine kinase (BTK) and can be used for the treatment of rheumatoid arthritis (RA).

Biological Activity

cnx-774 is an orally active and selective inhibitor of btk with ic50 value of <1 nm.bruton’s tyrosine kinase (btk) is an important enzyme in the b-cell antigen receptor (bcr) signaling pathway and also plays an important role in mast cell activation and b cell maturation.cnx-774 is an orally active, irreversible and selective btk inhibitor with ic50 value of <1 nm. cnx-774 formed covalent bond with the cys481 residue within the atp binding site of btk. in cellular assays, cnx-774 inhibited btk with ic50 values of 1-10 nm [1].

References

[1]. akinleye a, chen y, mukhi n, et al. ibrutinib and novel btk inhibitors in clinical development. j hematol oncol, 2013, 6: 59.

CNX-774 Preparation Products And Raw materials

Raw materials

Preparation Products

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CNX-774 Suppliers

China 106 India 2 United States 13 Global 121
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from CNX-774 manufacturers

Career Henan Chemical Co
Product
CNX-774 1202759-32-7
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

1202759-32-7, CNX-774Related Search:

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  • CNX-774
  • 4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
  • 4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
  • 4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide CNX-774
  • 4-(4-((4-((3-Acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamid
  • 2-Pyridinecarboxamide, 4-[4-[[5-fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-
  • 4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide
  • CNX774; CNX 774
  • 4-(4-((4-(acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
  • CS-946
  • CNX-774(97 %)
  • CNX-774 USP/EP/BP
  • CNX-77
  • CNX-774, 10 mM in DMSO
  • 1202759-32-7
  • C26H22FN7O3
  • Inhibitors
  • API