CNX-774
- Product Name
- CNX-774
- CAS No.
- 1202759-32-7
- Chemical Name
- CNX-774
- Synonyms
- CS-946;CNX-77;CNX-774;CNX-774(97 %);CNX774; CNX 774;CNX-774 USP/EP/BP;4-(4-((4-(acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide;4-(4-((4-((3-Acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamid;4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide;4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide
- CBNumber
- CB02666837
- Molecular Formula
- C26H22FN7O3
- Formula Weight
- 499.5
- MOL File
- 1202759-32-7.mol
CNX-774 Property
- Density
- 1.383±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20° C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 13.22±0.70(Predicted)
- CAS DataBase Reference
- 1202759-32-7
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21475
- Product name
- CNX-774
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 21475
- Product name
- CNX-774
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 21475
- Product name
- CNX-774
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $223
- Updated
- 2024/03/01
- Product number
- 21475
- Product name
- CNX-774
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $469
- Updated
- 2024/03/01
- Product number
- C600000
- Product name
- CNX-774
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
CNX-774 Chemical Properties,Usage,Production
Uses
CNX-774 is an irreversible, orally active, and highly selective inhibitor of Bruton’s tyrosine kinase (BTK) and can be used for the treatment of rheumatoid arthritis (RA).
Biological Activity
cnx-774 is an orally active and selective inhibitor of btk with ic50 value of <1 nm.bruton’s tyrosine kinase (btk) is an important enzyme in the b-cell antigen receptor (bcr) signaling pathway and also plays an important role in mast cell activation and b cell maturation.cnx-774 is an orally active, irreversible and selective btk inhibitor with ic50 value of <1 nm. cnx-774 formed covalent bond with the cys481 residue within the atp binding site of btk. in cellular assays, cnx-774 inhibited btk with ic50 values of 1-10 nm [1].
References
[1]. akinleye a, chen y, mukhi n, et al. ibrutinib and novel btk inhibitors in clinical development. j hematol oncol, 2013, 6: 59.
CNX-774 Preparation Products And Raw materials
Raw materials
Preparation Products
CNX-774 Suppliers
View Lastest Price from CNX-774 manufacturers
- Product
- CNX-774 1202759-32-7
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24