ChemicalBook > CAS DataBase List > 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

Product Name: 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
CAS No.: 23819-87-6
Chemical Name: 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
Synonyms: 5-Bromo-3-cyano-2-hydroxy-4,6-dimethylpyridine, 98%;5-Bromo-2-hydroxy-4,6-dimethylpyridine-3-carbonitrile;5-bromo-4,6-dimethyl-2-oxo-1H-pyridine-3-carbonitrile;5-BROMO-4,6-DIMETHYL-2-HYDROXYPYRIDINE-3-CARBONITRILE;5-Bromo-1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinecarbonitrile;5-BroMo-4,6-diMethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile;5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE;3-Pyridinecarbonitrile, 5-bromo-1,2-dihydro-4,6-dimethyl-2-oxo-;5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE ISO 9001：2015 REACH
CBNumber: CB0266169
Molecular Formula: C8H7BrN2O
Formula Weight: 227.06
MOL File: 23819-87-6.mol

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5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE Property

Melting point:: 263-266°C
Boiling point:: 301℃
Density: 1.61
Flash point:: 136℃
storage temp.: Inert atmosphere,Room Temperature
pka: 7.00±0.10(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 23819-87-6

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Safety

Risk Statements: 20/21/22-36/37/38
Safety Statements: 9-26-36/37
RIDADR: UN3439
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B293020
Product name: 5-Bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 044303
Product name: 5-Bromo-4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
Purity: >95%
Packaging: 500mg
Price: $51
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB132923
Product name: 5-Bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Packaging: 250mg
Price: $85
Updated: 2021/12/16

Matrix Scientific

Product number: 044303
Product name: 5-Bromo-4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
Purity: >95%
Packaging: 1g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB132923
Product name: 5-Bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Packaging: 500mg
Price: $150
Updated: 2021/12/16

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5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

769-28-8

23819-87-6

General procedure for the synthesis of 2-hydroxy-3-cyano-4,6-dimethyl-5-bromopyridine from 2-oxo-4,6-dimethyl-1,2-dihydropyridine-3-carbonitrile: To a solution of 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (35 g, 236 mmol) in acetic acid (200 ml) is added slowly and dropwise bromine (41.5 g, 260 mmol). 260 mmol). The reaction mixture was stirred at room temperature for 30 minutes. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The crude product was purified by recrystallization from ethanol-water mixed solvent to afford 5-bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (70 g, 95% yield). The product was analyzed by LCMS (Table 1, method c) showing retention time RT = 1.63 min; mass spectrum m/z = 226,228 (M + H).

References

[1] Journal of Organic Chemistry, 1984, vol. 49, # 26, p. 5237 - 5243
[2] Patent: WO2016/198908, 2016, A1. Location in patent: Page/Page column 76
[3] Pharmaceutical Chemistry Journal, 1989, vol. 23, # 12, p. 983 - 986
[4] Khimiko-Farmatsevticheskii Zhurnal, 1989, vol. 23, # 12, p. 1459 - 1463
[5] Journal of Heterocyclic Chemistry, 2011, vol. 48, # 2, p. 272 - 278

5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE 23819-87-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

23819-87-6, 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILERelated Search:

4,6-Dimethyl-2-hydroxypyridine 1-BROMO-2-METHYL-BUT-2-ENE 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE 3-Bromo-2-methylpropene 3,3-Dimethylallyl bromide 3-Cyano-4,6-dimethyl-2-hydroxypyridine

5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

5-BROMO-4,6-DIMETHYL-2-HYDROXYPYRIDINE-3-CARBONITRILE

5-Bromo-3-cyano-2-hydroxy-4,6-dimethylpyridine, 98%

5-Bromo-2-hydroxy-4,6-dimethylpyridine-3-carbonitrile

5-BroMo-4,6-diMethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

5-Bromo-1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinecarbonitrile

3-Pyridinecarbonitrile, 5-bromo-1,2-dihydro-4,6-dimethyl-2-oxo-

5-bromo-4,6-dimethyl-2-oxo-1H-pyridine-3-carbonitrile

5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE ISO 9001：2015 REACH

23819-87-6

C8H7BrN2O