ChemicalBook > CAS DataBase List > 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

Product Name
5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
CAS No.
23819-87-6
Chemical Name
5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
Synonyms
5-Bromo-3-cyano-2-hydroxy-4,6-dimethylpyridine, 98%;5-Bromo-2-hydroxy-4,6-dimethylpyridine-3-carbonitrile;5-bromo-4,6-dimethyl-2-oxo-1H-pyridine-3-carbonitrile;5-BROMO-4,6-DIMETHYL-2-HYDROXYPYRIDINE-3-CARBONITRILE;5-Bromo-1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinecarbonitrile;5-BroMo-4,6-diMethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile;5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE;3-Pyridinecarbonitrile, 5-bromo-1,2-dihydro-4,6-dimethyl-2-oxo-;5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE ISO 9001：2015 REACH
CBNumber
CB0266169
Molecular Formula
C8H7BrN2O
Formula Weight
227.06
MOL File
23819-87-6.mol
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5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE Property

Melting point:
263-266°C
Boiling point:
301℃
Density 
1.61
Flash point:
136℃
storage temp. 
Inert atmosphere,Room Temperature
pka
7.00±0.10(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
23819-87-6
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Safety

Risk Statements 
20/21/22-36/37/38
Safety Statements 
9-26-36/37
RIDADR 
UN3439
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B293020
Product name
5-Bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Packaging
100mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
044303
Product name
5-Bromo-4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
Purity
>95%
Packaging
500mg
Price
$51
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB132923
Product name
5-Bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Packaging
250mg
Price
$85
Updated
2021/12/16
Matrix Scientific
Product number
044303
Product name
5-Bromo-4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
Purity
>95%
Packaging
1g
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB132923
Product name
5-Bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Packaging
500mg
Price
$150
Updated
2021/12/16
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5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

769-28-8

23819-87-6

General procedure for the synthesis of 2-hydroxy-3-cyano-4,6-dimethyl-5-bromopyridine from 2-oxo-4,6-dimethyl-1,2-dihydropyridine-3-carbonitrile: To a solution of 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (35 g, 236 mmol) in acetic acid (200 ml) is added slowly and dropwise bromine (41.5 g, 260 mmol). 260 mmol). The reaction mixture was stirred at room temperature for 30 minutes. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The crude product was purified by recrystallization from ethanol-water mixed solvent to afford 5-bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (70 g, 95% yield). The product was analyzed by LCMS (Table 1, method c) showing retention time RT = 1.63 min; mass spectrum m/z = 226,228 (M + H).

References

[1] Journal of Organic Chemistry, 1984, vol. 49, # 26, p. 5237 - 5243
[2] Patent: WO2016/198908, 2016, A1. Location in patent: Page/Page column 76
[3] Pharmaceutical Chemistry Journal, 1989, vol. 23, # 12, p. 983 - 986
[4] Khimiko-Farmatsevticheskii Zhurnal, 1989, vol. 23, # 12, p. 1459 - 1463
[5] Journal of Heterocyclic Chemistry, 2011, vol. 48, # 2, p. 272 - 278

5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE Suppliers

China 43 Finland 1 France 1 Germany 1 India 1 Ukraine 1 United Kingdom 3 United States 10 Global 61
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE 23819-87-6
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25

23819-87-6, 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILERelated Search:

4,6-Dimethyl-2-hydroxypyridine 1-BROMO-2-METHYL-BUT-2-ENE 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE 3-Bromo-2-methylpropene 3,3-Dimethylallyl bromide 3-Cyano-4,6-dimethyl-2-hydroxypyridine

  • 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
  • 5-BROMO-4,6-DIMETHYL-2-HYDROXYPYRIDINE-3-CARBONITRILE
  • 5-Bromo-3-cyano-2-hydroxy-4,6-dimethylpyridine, 98%
  • 5-Bromo-2-hydroxy-4,6-dimethylpyridine-3-carbonitrile
  • 5-BroMo-4,6-diMethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
  • 5-Bromo-1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinecarbonitrile
  • 3-Pyridinecarbonitrile, 5-bromo-1,2-dihydro-4,6-dimethyl-2-oxo-
  • 5-bromo-4,6-dimethyl-2-oxo-1H-pyridine-3-carbonitrile
  • 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE ISO 9001：2015 REACH
  • 23819-87-6
  • C8H7BrN2O