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NS-6180

Product Name
NS-6180
CAS No.
353262-04-1
Chemical Name
NS-6180
Synonyms
NS6180;NS 6180;CS-1648;NS-6180;NS6180 >=98% (HPLC);NS6180;NS-6180;NS 6180;4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one;2H-1,4-Benzothiazin-3(4H)-one, 4-[[3-(trifluoromethyl)phenyl]methyl]-
CBNumber
CB02667182
Molecular Formula
C16H12F3NOS
Formula Weight
323.33
MOL File
353262-04-1.mol
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NS-6180 Property

Boiling point:
476.9±45.0 °C(Predicted)
Density 
1.375±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: soluble20mg/mL, clear
pka
0.53±0.20(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xi,N
Risk Statements 
43-51/53
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0745
Product name
NS6180
Purity
≥98% (HPLC)
Packaging
5mg
Price
$119
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0745
Product name
NS6180
Purity
≥98% (HPLC)
Packaging
25mg
Price
$428
Updated
2022/05/15
Cayman Chemical
Product number
14664
Product name
NS 6180
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
14664
Product name
NS 6180
Purity
≥98%
Packaging
10mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
14664
Product name
NS 6180
Purity
≥98%
Packaging
25mg
Price
$356
Updated
2024/03/01
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NS-6180 Chemical Properties,Usage,Production

Uses

NS 6180 increases the proliferation of both A-NK and NA-NK cells. NS 6180 is a new KCa3.1 channel inhibitor that prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.

Biological Activity

ns 6180 is a potent kca3.1 channel blocker. kca3.1 (the ca2+-activated k+ channel, encoded by the kcnn4 gene) plays a key role in these processes by participating in the regulation of calcium entry.

in vitro

ns6180 blocked cloned human kca3.1 channels via t250 and v275, while the same amino acid residues conferred sensitivity to triarylmethanes such as like tram-34. ns6180 blocked endogenously expressed kca3.1 channels in human, mouse and rat erythrocytes with similar potencies. rat and mouse splenocyte proliferation was suppressed ns6180 at submicrolar concentrations, which potently inhibited il-2 and ifn-g production, exerting smaller effects on il-4 and tnf-a and no effect on il-17 production. after induction of colitis, antibody staining exhibited kca3.1 channels in healthy colon and strong up-regulation in association with infiltrating immune cells [1].

in vivo

despite poor plasma exposure, ns6180 (3 and 10 mg·kg-1 b.i.d.) abolished colon inflammation and improved body weight gain effectively, just as the standard ibd drug sulfasalazine (300 mg·kg-1 q.d.). the benzothiazinone ns6180 was potent on recombinant and endogenously expressed kca3.1 channels, selectivity and molecular site of action. furthermore, the effect of ns6180 characterize its pharmacokinetics on the activity of t-lymphocytes from wild-type and kca3.1–/– knockout mice and show that it abolishes inflammation in an animal model of ibd [1].

IC 50

9, 14 and 15 nm for rat, human and mouse erythrocyte kca3.1 channels, respectively.

References

[1] strbk d, brown dt, jenkins dp, chen yj, coleman n, ando y, chiu p, jrgensen s, demnitz j, wulff h, christophersen p. ns6180, a new k(ca) 3.1 channel inhibitor prevents t-cell activation and inflammation in a rat model of inflammatory bowel disease. br j pharmacol. 2013 jan;168(2):432-44.

NS-6180 Preparation Products And Raw materials

Raw materials

Preparation Products

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NS-6180 Suppliers

Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30
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View Lastest Price from NS-6180 manufacturers

Career Henan Chemical Co
Product
4-[3-(Trifluoromethyl)benzyl]-2H-1,4-benzothiazin-3(4H)-one 353262-04-1
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

353262-04-1, NS-6180Related Search:


  • NS 6180
  • NS6180
  • NS-6180
  • 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one
  • NS6180;NS-6180;NS 6180
  • CS-1648
  • 2H-1,4-Benzothiazin-3(4H)-one, 4-[[3-(trifluoromethyl)phenyl]methyl]-
  • NS6180 >=98% (HPLC)
  • 353262-04-1
  • Inhibitors