NS 1738
- Product Name
- NS 1738
- CAS No.
- 501684-93-1
- Chemical Name
- NS 1738
- Synonyms
- NS 1738;NSC 213859;NS 1738 (NSC 213859);1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea;N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea;Urea, N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-;NS 1738,Nicotinic acetylcholine receptors,NSC213859,inhibit,Inhibitor,nAChR,NS-1738,NSC-213859,NS1738
- CBNumber
- CB42455756
- Molecular Formula
- C14H9Cl2F3N2O2
- Formula Weight
- 365.13
- MOL File
- 501684-93-1.mol
NS 1738 Property
- Boiling point:
- 344.1±42.0 °C(Predicted)
- Density
- 1.617±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- White crystalline solid.
- pka
- 8.08±0.13(Predicted)
- color
- Off-White to Light Grey
N-Bromosuccinimide Price
- Product number
- 5.05983
- Product name
- NS1738 - CAS 501684-93-1 - Calbiochem
- Packaging
- 10MG
- Price
- $182
- Updated
- 2024/03/01
- Product number
- 21018
- Product name
- NS 1738
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21018
- Product name
- NS 1738
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 21018
- Product name
- NS 1738
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 2995
- Product name
- NS1738
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $702
- Updated
- 2021/12/16
NS 1738 Chemical Properties,Usage,Production
Description
NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.
Uses
NS 1738 is a selective a7 nAchR allosteric modulator.
Biological Activity
Selective positive allosteric modulator of α 7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α 4 β 2, α 3 β 3 and α 1-containing receptors. Displays cognitive-enhancing properties in vivo .
storage
Store at RT
NS 1738 Preparation Products And Raw materials
Raw materials
Preparation Products
NS 1738 Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 888-539-0666
- Fax
- 888-539-0666
- info@emmx.com
- Country
- United States
- ProdList
- 8449
- Advantage
- 60
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 3445
- Advantage
- 55
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8003
- Advantage
- 62
- Tel
- 13761635123
- Fax
- 1014988033@qq
- 1014988033@qq.com
- Country
- China
- ProdList
- 4979
- Advantage
- 55
- Tel
- 0755-0755-85201366 18938635012
- Fax
- 0755-85201366
- sales@regentsciences.com
- Country
- China
- ProdList
- 9293
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3238
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58