ChemicalBook > CAS DataBase List > NS 1738

NS 1738

Product Name
NS 1738
CAS No.
501684-93-1
Chemical Name
NS 1738
Synonyms
NS 1738;NSC 213859;NS 1738 (NSC 213859);NS 1738, 10 mM in DMSO;1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea;N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea;Urea, N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-;NS 1738,Nicotinic acetylcholine receptors,NSC213859,inhibit,Inhibitor,nAChR,NS-1738,NSC-213859,NS1738
CBNumber
CB42455756
Molecular Formula
C14H9Cl2F3N2O2
Formula Weight
365.13
MOL File
501684-93-1.mol
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NS 1738 Property

Boiling point:
344.1±42.0 °C(Predicted)
Density 
1.617±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
White crystalline solid.
pka
8.08±0.13(Predicted)
color 
Off-White to Light Grey
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05983
Product name
NS1738 - CAS 501684-93-1 - Calbiochem
Packaging
10MG
Price
$182
Updated
2024/03/01
Cayman Chemical
Product number
21018
Product name
NS 1738
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21018
Product name
NS 1738
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
21018
Product name
NS 1738
Purity
≥98%
Packaging
10mg
Price
$139
Updated
2024/03/01
Tocris
Product number
2995
Product name
NS1738
Purity
≥99%(HPLC)
Packaging
10
Price
$167
Updated
2021/12/16
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NS 1738 Chemical Properties,Usage,Production

Description

NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.

Uses

NS 1738 is a selective a7 nAchR allosteric modulator.

Biological Activity

Selective positive allosteric modulator of α 7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α 4 β 2, α 3 β 3 and α 1-containing receptors. Displays cognitive-enhancing properties in vivo .

in vivo

To estimate the ability of NS 1738 to permeate the blood-brain barrier, rats are administered 10 mg/kg NS 1738 intraperitoneally. Peak brain concentrations are measured approximately 30 min after injection, and they amount to ~80 ng/mL (~200 nM) at this dose. The ratio between the amount of compound entering the brain and that in plasma is AUCbrain /AUCplasma=0.50. The half-life in plasma is estimated to 42 min. Incubation of NS1738 with isolated liver microsomes in vitro indicates that approximately 60 and 75% of NS 1738 is metabolized via the cytochrome P450 system in mouse and rat, respectively, within 1 h. Adult rats administered NS 1738 at 10 and 30 mg/kg i.p. immediately following the initial exposure to a juvenile rat (T1) display significant decreases in the investigative duration of a subsequent exposure to the same juvenile (T2) 2 h later (T2/T1 ratio of 0.69±0.13 and 0.61±0.07, respectively)[1].

storage

Store at RT

References

[1] DANIEL B TIMMERMANN. An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo.[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 323 1: 294-307. DOI: 10.1124/jpet.107.120436
[2] QING CHENG  Jerrel L Y. Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation.[J]. Journal of Neuroscience, 2014: 124-133. DOI: 10.1523/jneurosci.2973-13.2014
[3] KELEN FREITAS M I D F Ivy Carroll. The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.[J]. Journal of Pharmacology and Experimental Therapeutics, 2013, 344 1: 264-275. DOI: 10.1124/jpet.112.197871

NS 1738 Preparation Products And Raw materials

Raw materials

Preparation Products

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NS 1738 Suppliers

China 68 India 1 United Kingdom 2 United States 9 USA 1 Global 81
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
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69
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
1014988033@qq.com
Country
China
ProdList
4941
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55
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9751
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58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3277
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58

501684-93-1, NS 1738Related Search:

NS1652 NS1643 NS-6180 NS 1738

  • NS 1738
  • N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea
  • NSC 213859
  • 1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea
  • Urea, N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-
  • NS 1738 (NSC 213859)
  • NS 1738,Nicotinic acetylcholine receptors,NSC213859,inhibit,Inhibitor,nAChR,NS-1738,NSC-213859,NS1738
  • NS 1738, 10 mM in DMSO
  • 501684-93-1