NS 1738

ChemicalBook > CAS DataBase List > NS 1738

Product Name: NS 1738
CAS No.: 501684-93-1
Chemical Name: NS 1738
Synonyms: NS 1738;NSC 213859;NS 1738 (NSC 213859);1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea;N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea;Urea, N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-;NS 1738,Nicotinic acetylcholine receptors,NSC213859,inhibit,Inhibitor,nAChR,NS-1738,NSC-213859,NS1738
CBNumber: CB42455756
Molecular Formula: C14H9Cl2F3N2O2
Formula Weight: 365.13
MOL File: 501684-93-1.mol

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NS 1738 Property

Boiling point:: 344.1±42.0 °C(Predicted)
Density: 1.617±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMSO (Slightly), Methanol (Slightly)
form: White crystalline solid.
pka: 8.08±0.13(Predicted)
color: Off-White to Light Grey

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.05983
Product name: NS1738 - CAS 501684-93-1 - Calbiochem
Packaging: 10MG
Price: $182
Updated: 2024/03/01

Cayman Chemical

Product number: 21018
Product name: NS 1738
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21018
Product name: NS 1738
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 21018
Product name: NS 1738
Purity: ≥98%
Packaging: 10mg
Price: $139
Updated: 2024/03/01

Tocris

Product number: 2995
Product name: NS1738
Purity: ≥99%(HPLC)
Packaging: 50
Price: $702
Updated: 2021/12/16

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NS 1738 Chemical Properties,Usage,Production

Description

NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC₅₀ = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.

Uses

NS 1738 is a selective a7 nAchR allosteric modulator.

Biological Activity

Selective positive allosteric modulator of α 7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α 4 β 2, α 3 β 3 and α 1-containing receptors. Displays cognitive-enhancing properties in vivo .

storage

Store at RT

NS 1738 Preparation Products And Raw materials

Raw materials

Preparation Products

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501684-93-1, NS 1738Related Search:

NS1652 NS1643 NS-6180 NS 1738

NS 1738

N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea

NSC 213859

1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea

Urea, N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-

NS 1738 (NSC 213859)

NS 1738,Nicotinic acetylcholine receptors,NSC213859,inhibit,Inhibitor,nAChR,NS-1738,NSC-213859,NS1738

501684-93-1