b-AP15
- Product Name
- b-AP15
- CAS No.
- 330450-45-8
- Chemical Name
- b-AP15
- Synonyms
- b-AP15;NSC-687852;NSC687852 >=98% (HPLC);(3Z,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-piperidin-4-one;4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-
- CBNumber
- CB02667632
- Molecular Formula
- C22H17N3O6
- Formula Weight
- 419.39
- MOL File
- 330450-45-8.mol
b-AP15 Property
- Boiling point:
- 670.4±55.0 °C(Predicted)
- Density
- 1.416±0.06 g/cm3(Predicted)
- pka
- -1.39±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- 4566
- Product name
- NSC687852
- Purity
- ≥97%(HPLC)
- Packaging
- 10
- Price
- $149
- Updated
- 2021/12/16
- Product number
- 4566
- Product name
- NSC687852
- Purity
- ≥97%(HPLC)
- Packaging
- 50
- Price
- $549
- Updated
- 2021/12/16
- Product number
- 256062
- Product name
- NSC 687852
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- P000532871
- Product name
- b-AP15
- Purity
- 98+%
- Packaging
- 100mg
- Price
- $509
- Updated
- 2021/12/16
- Product number
- P000532871
- Product name
- b-AP15
- Purity
- 98+%
- Packaging
- 250mg
- Price
- $814
- Updated
- 2021/12/16
b-AP15 Chemical Properties,Usage,Production
Enzyme inhibitor
This deubiquitinase inhibitor (FW = 421.31 g/mol; CAS 1009817-63-3), also named 3,5-bis[ (4-nitrophenyl) methylene]-1- (1-oxo-2-propen-1-yl) - (3E,5E) -4-piperidinone, targets two proteasome-associated ubiquitin carboxyl-terminal hydrolase-14, or USP14, and Ubiquitin Carboxyl-terminal Hydrolase isozyme L5 UCHL5, IC50 = 2.1 μM, resulting in a rapid accumulation of high-molecular-weight ubiquitin conjugates and functional shutdown of proteasome. Interestingly, b-AP15 displays several differences with respect to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in solid tumor models. Inhibition of DUBs blocked the processing and release of interleukin IL-1β in both mouse and human macrophages. DUB activity was necessary for inflammasome association as DUB inhibition also impaired ASC oligomerization and caspase-1 activation without directly blocking caspase- 1 activity. These data reveal the requirement for DUB activity in a key reaction of the innate immune response and highlight the therapeutic potential of DUB inhibitors for chronic auto-inflammatory diseases. (See also Bortezomib, Eeeyarestatin I)
b-AP15 Preparation Products And Raw materials
Raw materials
Preparation Products
b-AP15 Suppliers
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