1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)-
- Product Name
- 1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)-
- CAS No.
- 878006-06-5
- Chemical Name
- 1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)-
- Synonyms
- (E)-[6]-Dehydroparadol;(E)-[6]-Dehydroparadol, 10 mM in DMSO;1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)-
- CBNumber
- CB02667672
- Molecular Formula
- C17H24O3
- Formula Weight
- 276.37
- MOL File
- 878006-06-5.mol
1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)- Property
- Boiling point:
- 423.2±30.0 °C(Predicted)
- Density
- 1.040±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 140 mg/mL (506.57 mM)
- pka
- 9.76±0.31(Predicted)
- form
- Solid
- color
- Yellow to orange
N-Bromosuccinimide Price
- Product number
- CS-M1954
- Product name
- (E)-[6]-Dehydroparadol
- Packaging
- 5mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- CS-M1954
- Product name
- (E)-[6]-Dehydroparadol
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-M1954
- Product name
- (E)-[6]-Dehydroparadol
- Packaging
- 50mg
- Price
- $456
- Updated
- 2021/12/16
- Product number
- CS-M1954
- Product name
- (E)-[6]-Dehydroparadol
- Packaging
- 100mg
- Price
- $576
- Updated
- 2021/12/16
- Product number
- CS-M1954
- Product name
- (E)-[6]-Dehydroparadol
- Packaging
- 500mg
- Price
- $1176
- Updated
- 2021/12/16
1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)- Chemical Properties,Usage,Production
Uses
(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol (HY-14616), is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells[1][2].
in vivo
(E)-[6]-Dehydroparadol (compound 19) (5 μM; 24 h) enhances Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] fluorescence signal in the Tg(gstp1:GFP) transgenic zebrafish embryos[2].
References
[1] Chen H, et, al. Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. Mol Nutr Food Res. 2013 May;57(5):865-76. DOI:10.1002/mnfr.201200708
[2] Zhu Y, et, al. Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators. Free Radic Biol Med. 2016 Jun;95:243-54. DOI:10.1016/j.freeradbiomed.2016.03.026
1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)- Preparation Products And Raw materials
Raw materials
Preparation Products
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