ChemicalBook > CAS DataBase List > NSC 55712

NSC 55712

Product Name: NSC 55712
CAS No.: 2076-91-7
Chemical Name: NSC 55712
Synonyms: R 55;NSC 55712;TPT-260 2HCl;TPT-260 , NSC55712;TPT-260 2HCl (R55);TPT-260 2HCl(NSC55712);TPT-260 (hydrochloride);TPU-260 Dihydrochloride;NSC55712 Dihydrochloride;TPT-260 (Dihydrochloride)
CBNumber: CB02667773
Molecular Formula: C8H14Cl2N4S3
Formula Weight: 333.32456
MOL File: 2076-91-7.mol

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NSC 55712 Property

Melting point:: 210℃ (Decomposition)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO:62.5(Max Conc. mg/mL);240.02(Max Conc. mM)
form: A crystalline solid
color: Light yellow to yellow
Water Solubility: water: 50mg/mL

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16079
Product name: TPT-260 (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16079
Product name: TPT-260 (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $140
Updated: 2024/03/01

Cayman Chemical

Product number: 16079
Product name: TPT-260 (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $235
Updated: 2024/03/01

Cayman Chemical

Product number: 16079
Product name: TPT-260 (hydrochloride)
Purity: ≥95%
Packaging: 25mg
Price: $479
Updated: 2024/03/01

AK Scientific

Product number: SYN5349
Product name: R55
Packaging: 50mg
Price: $757
Updated: 2021/12/16

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NSC 55712 Chemical Properties,Usage,Production

Uses

Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 μM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.[Cayman Chemical]

Biological Activity

Cell permeable: yes', 'Primary Target
vacuolar protein sorting (Vps) proteins', 'Reversible: yes

NSC 55712 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC 55712 Suppliers

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2076-91-7, NSC 55712Related Search:

NSC 55712

TPT-260 (Dihydrochloride)

THIOPHENE-2,5-DIYLBIS(METHYLENE) DICARBAMIMIDOTHIOATE.2HCL

TPT-260 (Dihydrochloride), NSC55712

TPT-260 2HCl

Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride

Carbamimidothioic acid,C,C'-[2,5-thiophenediylbis(methylene)] ester, hydrochloride (1:2)

TPT-260 , NSC55712

NSC 55712 Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride

TPT-260 Dihydrochloride, >=98%

Thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride

NSC55712 Dihydrochloride

TPT-260 2HCl(NSC55712)

R 55

TPT-260 (hydrochloride)

thiene-2,5-diyldimethanediyl dicarbamimidothioate

NSC55712; TPT260 DIHYDROCHLORIDE; TPT 260 DIHYDROCHLORIDE; TPU-260 DIHYDROCHLORIDE;NSC-55712;NSC 55712

TPU-260 Dihydrochloride

[({5-[(carbamimidoylsulfanyl)methyl]thiophen-2-yl}methyl)sulfanyl]methanimidamide dihydrochloride

TPT-260 2HCl (R55)

TPT 260 Dihydrochloride,Inhibitor,inhibit,TPU 260,TPU260,TPT260 Dihydrochloride,NSC 55712,TPU-260,NSC-55712

Carbamimidothioic acid, C,C'-[2,5-thiophenediylbis(methylene)] ester, hydrochloride (1:2)

TPT-260 Dihydrochloride, 10 mM in DMSO

2076-91-7

C8H12N4S32HCl

C8H14Cl2N4S3

C8H12N4S32ClH

Inhibitors