ChemicalBook > CAS DataBase List > NSC 55712

NSC 55712

Product Name
NSC 55712
CAS No.
2076-91-7
Chemical Name
NSC 55712
Synonyms
R 55;NSC 55712;TPT-260 2HCl;TPT-260 , NSC55712;TPT-260 2HCl (R55);TPT-260 2HCl(NSC55712);TPT-260 (hydrochloride);TPU-260 Dihydrochloride;NSC55712 Dihydrochloride;TPT-260 (Dihydrochloride)
CBNumber
CB02667773
Molecular Formula
C8H14Cl2N4S3
Formula Weight
333.32456
MOL File
2076-91-7.mol
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NSC 55712 Property

Melting point:
210℃ (Decomposition)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO:62.5(Max Conc. mg/mL);240.02(Max Conc. mM)
form 
A crystalline solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16079
Product name
TPT-260 (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
16079
Product name
TPT-260 (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$140
Updated
2024/03/01
Cayman Chemical
Product number
16079
Product name
TPT-260 (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$235
Updated
2024/03/01
Cayman Chemical
Product number
16079
Product name
TPT-260 (hydrochloride)
Purity
≥95%
Packaging
25mg
Price
$479
Updated
2024/03/01
AK Scientific
Product number
SYN5349
Product name
R55
Packaging
50mg
Price
$757
Updated
2021/12/16
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NSC 55712 Chemical Properties,Usage,Production

Uses

Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 μM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.[Cayman Chemical]

NSC 55712 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC 55712 Suppliers

China 45 India 1 The Netherlands 1 United States 12 Global 59
Haoyuan Chemexpress Co., Ltd.
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2076-91-7, NSC 55712Related Search:


  • NSC 55712
  • TPT-260 (Dihydrochloride)
  • THIOPHENE-2,5-DIYLBIS(METHYLENE) DICARBAMIMIDOTHIOATE.2HCL
  • TPT-260 (Dihydrochloride), NSC55712
  • TPT-260 2HCl
  • Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride
  • Carbamimidothioic acid,C,C'-[2,5-thiophenediylbis(methylene)] ester, hydrochloride (1:2)
  • TPT-260 , NSC55712
  • NSC 55712 Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride
  • TPT-260 Dihydrochloride, >=98%
  • Thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride
  • NSC55712 Dihydrochloride
  • TPT-260 2HCl(NSC55712)
  • R 55
  • TPT-260 (hydrochloride)
  • thiene-2,5-diyldimethanediyl dicarbamimidothioate
  • NSC55712; TPT260 DIHYDROCHLORIDE; TPT 260 DIHYDROCHLORIDE; TPU-260 DIHYDROCHLORIDE;NSC-55712;NSC 55712
  • TPU-260 Dihydrochloride
  • [({5-[(carbamimidoylsulfanyl)methyl]thiophen-2-yl}methyl)sulfanyl]methanimidamide dihydrochloride
  • TPT-260 2HCl (R55)
  • TPT 260 Dihydrochloride,Inhibitor,inhibit,TPU 260,TPU260,TPT260 Dihydrochloride,NSC 55712,TPU-260,NSC-55712
  • Carbamimidothioic acid, C,C'-[2,5-thiophenediylbis(methylene)] ester, hydrochloride (1:2)
  • 2076-91-7
  • C8H12N4S32HCl
  • C8H14Cl2N4S3
  • C8H12N4S32ClH
  • Inhibitors