NSC 55712
- Product Name
- NSC 55712
- CAS No.
- 2076-91-7
- Chemical Name
- NSC 55712
- Synonyms
- R 55;NSC 55712;TPT-260 2HCl;TPT-260 , NSC55712;TPT-260 2HCl (R55);TPT-260 2HCl(NSC55712);TPT-260 (hydrochloride);TPU-260 Dihydrochloride;NSC55712 Dihydrochloride;TPT-260 (Dihydrochloride)
- CBNumber
- CB02667773
- Molecular Formula
- C8H14Cl2N4S3
- Formula Weight
- 333.32456
- MOL File
- 2076-91-7.mol
NSC 55712 Property
- Melting point:
- 210℃ (Decomposition)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO:62.5(Max Conc. mg/mL);240.02(Max Conc. mM)
- form
- A crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 16079
- Product name
- TPT-260 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 16079
- Product name
- TPT-260 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $140
- Updated
- 2024/03/01
- Product number
- 16079
- Product name
- TPT-260 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $235
- Updated
- 2024/03/01
- Product number
- 16079
- Product name
- TPT-260 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $479
- Updated
- 2024/03/01
- Product number
- SYN5349
- Product name
- R55
- Packaging
- 50mg
- Price
- $757
- Updated
- 2021/12/16
NSC 55712 Chemical Properties,Usage,Production
Uses
Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 μM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.[Cayman Chemical]