P 22077

ChemicalBook > CAS DataBase List > P 22077

Product Name: P 22077
CAS No.: 1247819-59-5
Chemical Name: P 22077
Synonyms: P 22077;CS-1115;P 22077; P-22077;P 22077 USP/EP/BP;USP7/USP47 Inhibitor, P 22077;1-(5-(2,4-difluorophenylthio)-4-nitrothiophen-2-yl)ethanone;1-[5-[(2,4-Difluorophenyl)thio]-4-n-itro-2-thienyl]-ethanone;1-[5-(2,4-difluorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone;Ethanone, 1-[5-[(2,4-difluorophenyl)thio]-4-nitro-2-thienyl]-;1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone
CBNumber: CB02668437
Molecular Formula: C12H7F2NO3S2
Formula Weight: 315.32
MOL File: 1247819-59-5.mol

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P 22077 Property

Melting point:: 146 - 148°C
Boiling point:: 395.4±42.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 25 mg/ml)
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 4485
Product name: P22077
Purity: ≥99%(HPLC)
Packaging: 10
Price: $201
Updated: 2021/12/16

Tocris

Product number: 4485
Product name: P22077
Purity: ≥99%(HPLC)
Packaging: 50
Price: $817
Updated: 2021/12/16

TRC

Product number: P122470
Product name: P22077
Packaging: 50mg
Price: $360
Updated: 2021/12/16

Usbiological

Product number: 256138
Product name: P 22077
Packaging: 10mg
Price: $446
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546205
Product name: P22077
Purity: >98%
Packaging: 50mg
Price: $472.6
Updated: 2021/12/16

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P 22077 Chemical Properties,Usage,Production

Description

P22077 (1247819-59-5) is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50?= 8 μM) and the closely related USP47.1,2?It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a DNA damage response enzyme.2?P22077 inhibits neuroblastoma growth?via?induction of p53-mediated apoptosis.3?N-Myc was destabilized by P22077 inhibition of USP7 in human neuroblastoma cells.4?It was able to stabilize p53 levels in conjunction with an Mdm2 inhibitor (Nutlin-3,?Cat# 10-1350)?in HCT116 colorectal carcinoma cells.5

Uses

P22077 is an analog of the ubiquitin-specific protease (USP7) inhibitor P5091. It inhibits USP7, as well.

storage

Store at +4°C

References

1) Tian?et al. (2011),?Characterization of Selective Ubiquitin and Ubiquitin-like Protease Inhibitors Using a Fluorescence-Based Multiplex Assay Format; Assay Drug Dev. Technol.?9?165 2) Altun?et al.?(2011),?Activity-based chemical proteomics accelerates inhibitor development for deubiquitinylating enzymes; Chem. Biol.?18?1401 3) Fan?et al.?(2013),?USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis;?Cell Death Dis.?4?e867 4) Tavana?et al.?(2016),?HAUSP deubiquitinates and stabilizes M-Myc in neuroblastoma; Nat. Med.?22?1180 5) Tavana?et al.?(2018),?Targeting HAUSP in both p53 wildtype and p53-mutant tumors; Cell Cycle?17?823

P 22077 Preparation Products And Raw materials

Raw materials

Preparation Products

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P 22077 Suppliers

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1247819-59-5, P 22077Related Search:

Ko 143 AG 490 AAL-993 Brefeldin A BAY 11-7082 PR-619 Degrasyn (WP1130) TCID P-5091 Thalidomide

P 22077

1-(5-(2,4-difluorophenylthio)-4-nitrothiophen-2-yl)ethanone

1-[5-[(2,4-Difluorophenyl)thio]-4-n-itro-2-thienyl]-ethanone

Ethanone, 1-[5-[(2,4-difluorophenyl)thio]-4-nitro-2-thienyl]-

1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]ethanone P 22077

P 22077 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]ethanone

1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone

CS-1115

P 22077; P-22077

USP7/USP47 Inhibitor, P 22077

P 22077 USP/EP/BP

1-[5-(2,4-difluorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone

1247819-59-5

C12H7F2NO3S2

Inhibitors