PR-619
- Product Name
- PR-619
- CAS No.
- 2645-32-1
- Chemical Name
- PR-619
- Synonyms
- PR-619;CS-1128;6-Diamino-3;PR-619;PR619;PR-619, >=98%;PR-619 USP/EP/BP;5-dithiocyanopyridine;2,6-DiaMino-3,5-dithiocyanopyridine;3,5-dithiocyanatopyridine-2,6-diaMine;3,5-Bis-thiocyanato-pyridine-2,6-diamine
- CBNumber
- CB82656906
- Molecular Formula
- C7H5N5S2
- Formula Weight
- 223.28
- MOL File
- 2645-32-1.mol
PR-619 Property
- Melting point:
- 210℃
- Boiling point:
- 406.0±45.0 °C(Predicted)
- Density
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble5mg/mL (clear solution)
- pka
- -0.19±0.50(Predicted)
- form
- powder
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41-43
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0430
- Product name
- PR-619
- Purity
- ≥95% (HPLC)
- Packaging
- 1mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- SML0430
- Product name
- PR-619
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $316
- Updated
- 2024/03/01
- Product number
- 16276
- Product name
- PR-619
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $59
- Updated
- 2024/03/01
- Product number
- 16276
- Product name
- PR-619
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $104
- Updated
- 2024/03/01
- Product number
- 16276
- Product name
- PR-619
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $156
- Updated
- 2024/03/01
PR-619 Chemical Properties,Usage,Production
Description
PR-619 (2645-32-1) is a nonselective, reversible inhibitor of cysteine-reactive deubiquitinating enzymes (DUBs; 5-20 μM)1. PR-619 is highly useful for preserving ubiquitinated proteins during cell lysis. DUBs become unregulated in cell lysates and will act quickly to deubiquitinate proteins of interest during cell lysis. To preserve maximum amounts of ubiquitinated protein, include PR-619 (50-100 μM) in lysis buffers. PR-619 is also useful for interrogating the role of DUBs in intact cell systems2, and treatment of cells results in an overall accumulation of ubiquitinated proteins and many other phenotypes.
Uses
PR 619 is a broad-range DUB inhibitor. A selective and general inhibitior of cellular DUB activity without direct impairment of proteasomal proteolysis. Used in the preparation of thiazolopyridines an d bisthiazolopyridines.
Uses
PR-619 has been used:
- as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cells
- as a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus (AAV) transduction
- in radioimmunoprecipitation assay buffer (RIPA) buffer used for ubiquitination assays
Biochem/physiol Actions
PR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.
storage
Store at -20°C
References
1) Altun?et al. (2011),?Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes; Chem. Biol.,?18?1401 2) Seiberlich?et al. (2012),?The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases; Biochim. Biophys. Acta,?1823?2057
PR-619 Preparation Products And Raw materials
Raw materials
Preparation Products
PR-619 Suppliers
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View Lastest Price from PR-619 manufacturers
- Product
- PR-619 2645-32-1
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-09-03