P 22077
- Product Name
- P 22077
- CAS No.
- 1247819-59-5
- Chemical Name
- P 22077
- Synonyms
- P 22077;CS-1115;P 22077; P-22077;P 22077 USP/EP/BP;USP7/USP47 Inhibitor, P 22077;1-(5-(2,4-difluorophenylthio)-4-nitrothiophen-2-yl)ethanone;1-[5-[(2,4-Difluorophenyl)thio]-4-n-itro-2-thienyl]-ethanone;1-[5-(2,4-difluorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone;Ethanone, 1-[5-[(2,4-difluorophenyl)thio]-4-nitro-2-thienyl]-;1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone
- CBNumber
- CB02668437
- Molecular Formula
- C12H7F2NO3S2
- Formula Weight
- 315.32
- MOL File
- 1247819-59-5.mol
P 22077 Property
- Melting point:
- 146 - 148°C
- Boiling point:
- 395.4±42.0 °C(Predicted)
- Density
- 1.53±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 25 mg/ml)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 4485
- Product name
- P22077
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $201
- Updated
- 2021/12/16
- Product number
- 4485
- Product name
- P22077
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $817
- Updated
- 2021/12/16
- Product number
- P122470
- Product name
- P22077
- Packaging
- 50mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- 256138
- Product name
- P 22077
- Packaging
- 10mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- orb546205
- Product name
- P22077
- Purity
- >98%
- Packaging
- 50mg
- Price
- $472.6
- Updated
- 2021/12/16
P 22077 Chemical Properties,Usage,Production
Description
P22077 (1247819-59-5) is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50?= 8 μM) and the closely related USP47.1,2?It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a DNA damage response enzyme.2?P22077 inhibits neuroblastoma growth?via?induction of p53-mediated apoptosis.3?N-Myc was destabilized by P22077 inhibition of USP7 in human neuroblastoma cells.4?It was able to stabilize p53 levels in conjunction with an Mdm2 inhibitor (Nutlin-3,?Cat# 10-1350)?in HCT116 colorectal carcinoma cells.5
Uses
P22077 is an analog of the ubiquitin-specific protease (USP7) inhibitor P5091. It inhibits USP7, as well.
storage
Store at +4°C
References
1) Tian?et al. (2011),?Characterization of Selective Ubiquitin and Ubiquitin-like Protease Inhibitors Using a Fluorescence-Based Multiplex Assay Format; Assay Drug Dev. Technol.?9?165 2) Altun?et al.?(2011),?Activity-based chemical proteomics accelerates inhibitor development for deubiquitinylating enzymes; Chem. Biol.?18?1401 3) Fan?et al.?(2013),?USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis;?Cell Death Dis.?4?e867 4) Tavana?et al.?(2016),?HAUSP deubiquitinates and stabilizes M-Myc in neuroblastoma; Nat. Med.?22?1180 5) Tavana?et al.?(2018),?Targeting HAUSP in both p53 wildtype and p53-mutant tumors; Cell Cycle?17?823
P 22077 Preparation Products And Raw materials
Raw materials
Preparation Products
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