ChemicalBook > CAS DataBase List > PR-619

PR-619

Product Name
PR-619
CAS No.
2645-32-1
Chemical Name
PR-619
Synonyms
PR-619;CS-1128;6-Diamino-3;PR-619;PR619;PR-619, >=98%;PR-619 USP/EP/BP;5-dithiocyanopyridine;2,6-DiaMino-3,5-dithiocyanopyridine;3,5-dithiocyanatopyridine-2,6-diaMine;3,5-Bis-thiocyanato-pyridine-2,6-diamine
CBNumber
CB82656906
Molecular Formula
C7H5N5S2
Formula Weight
223.28
MOL File
2645-32-1.mol
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PR-619 Property

Melting point:
210℃
Boiling point:
406.0±45.0 °C(Predicted)
Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble5mg/mL (clear solution)
pka
-0.19±0.50(Predicted)
form 
powder
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41-43
Safety Statements 
26-36/37/39
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0430
Product name
PR-619
Purity
≥95% (HPLC)
Packaging
1mg
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0430
Product name
PR-619
Purity
≥95% (HPLC)
Packaging
5mg
Price
$316
Updated
2024/03/01
Cayman Chemical
Product number
16276
Product name
PR-619
Purity
≥98%
Packaging
5mg
Price
$59
Updated
2024/03/01
Cayman Chemical
Product number
16276
Product name
PR-619
Purity
≥98%
Packaging
10mg
Price
$104
Updated
2024/03/01
Cayman Chemical
Product number
16276
Product name
PR-619
Purity
≥98%
Packaging
25mg
Price
$156
Updated
2024/03/01
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PR-619 Chemical Properties,Usage,Production

Description

PR-619 (2645-32-1) is a nonselective, reversible inhibitor of cysteine-reactive deubiquitinating enzymes (DUBs; 5-20 μM)1. PR-619 is highly useful for preserving ubiquitinated proteins during cell lysis. DUBs become unregulated in cell lysates and will act quickly to deubiquitinate proteins of interest during cell lysis. To preserve maximum amounts of ubiquitinated protein, include PR-619 (50-100 μM) in lysis buffers. PR-619 is also useful for interrogating the role of DUBs in intact cell systems2, and treatment of cells results in an overall accumulation of ubiquitinated proteins and many other phenotypes.

Uses

PR 619 is a broad-range DUB inhibitor. A selective and general inhibitior of cellular DUB activity without direct impairment of proteasomal proteolysis. Used in the preparation of thiazolopyridines an d bisthiazolopyridines.

Uses

PR-619 has been used:

  • as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cells
  • as a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus (AAV) transduction
  • in radioimmunoprecipitation assay buffer (RIPA) buffer used for ubiquitination assays

Biochem/physiol Actions

PR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.

storage

Store at -20°C

References

1) Altun?et al. (2011),?Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes; Chem. Biol.,?18?1401 2) Seiberlich?et al. (2012),?The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases; Biochim. Biophys. Acta,?1823?2057

PR-619 Preparation Products And Raw materials

Raw materials

Preparation Products

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PR-619 Suppliers

Canada 1 China 116 India 3 United Kingdom 1 United States 18 Global 139
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from PR-619 manufacturers

Career Henan Chemical Co
Product
PR-619 2645-32-1
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

2645-32-1, PR-619Related Search:

Ko 143 TYRPHOSTIN AG 1296 S-Trityl-L-cysteine (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Bortezomib Degrasyn (WP1130) PYR 41 MG-132 P-5091 P 22077

  • PR-619
  • 2,6-DiaMino-3,5-dithiocyanopyridine
  • 3,5-dithiocyanatopyridine-2,6-diaMine
  • Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester
  • 2,6-Diamino-3,5-dithiocyanopyridine PR 619
  • PR 619 2,6-Diamino-3,5-dithiocyanopyridine
  • 2,6-Diaminopyridine-3,5-bis(thiocyanate)
  • PR-619;PR619
  • 3,5-Bis-thiocyanato-pyridine-2,6-diamine
  • 2,6-Diamino-3,5-dithiocyanato-pyridin, 98%
  • PR-619, >=98%
  • 2;6-DIAMINO-3;5-DITHIOCYANOPYRIDINE;PR 619;PR619
  • 5-dithiocyanopyridine
  • 6-Diamino-3
  • CS-1128
  • PR-619 USP/EP/BP
  • (2,6-diamino-5-thiocyanatopyridin-3-yl)thiocyanate
  • DUBs,tau,G0/G1,Autophagy,PR-619,PR619,Deubiquitinase,ER-stress,ubiquitination,inhibit,Inhibitor,Apoptosis,arrest
  • Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester
  • 2645-32-1
  • Inhibitors