PYR 41
- Product Name
- PYR 41
- CAS No.
- 418805-02-4
- Chemical Name
- PYR 41
- Synonyms
- PYR 41;CS-1129;PYR 41, >=98%;PYR41; PYR-41;PYR 41 USP/EP/BP;Ethyl 4-(4-((5-nitrofuran-2-yl)methylene)-3,5-dioxopyrazolidin-1-yl)benzoate;ethyl 4-[(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl]benzoate;4[4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester;4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester;Benzoic acid, 4-[4-[(5-nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]-, ethyl ester
- CBNumber
- CB62535692
- Molecular Formula
- C17H13N3O7
- Formula Weight
- 371.3
- MOL File
- 418805-02-4.mol
PYR 41 Property
- Melting point:
- 228 - 235°C
- Density
- 1.486±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO at 5mg/ml with warming
- form
- powder
- pka
- 7.43±0.20(Predicted)
- color
- red to brown
- Sensitive
- Light Sensitive
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
- InChIKey
- ARGIPZKQJGFSGQ-LCYFTJDESA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- N2915
- Product name
- PYR-41
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $95.3
- Updated
- 2024/03/01
- Product number
- N2915
- Product name
- PYR-41
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $304
- Updated
- 2024/03/01
- Product number
- J65388
- Product name
- Ubiquitin E1 Inhibitor
- Purity
- PYR-41
- Packaging
- 25mg
- Price
- $227
- Updated
- 2023/06/20
- Product number
- J65388
- Product name
- Ubiquitin E1 Inhibitor
- Purity
- PYR-41
- Packaging
- 100mg
- Price
- $658
- Updated
- 2023/06/20
- Product number
- 15226
- Product name
- PYR41
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $26
- Updated
- 2024/03/01
PYR 41 Chemical Properties,Usage,Production
Description
Pyr41 (418805-02-4) inhibits ubiquitin activating enzyme E1 (>60% inhibition at 10 μM) with little or no activity against E2 or E3. Cell permeable
Uses
PYR 41 is an irreversible and cell-permeable UBE1 inhibitor.
Definition
ChEBI: PYR-41 is an ethyl ester resulting from the formal condensation of the carboxy group of 4-{4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl}benzoic acid with ethanol. It is an irreversible and cell-permeable inhibitor of ubiquitin-activating enzyme E1. It has a role as an EC 6.2.1.45 (E1 ubiquitin-activating enzyme) inhibitor and an antineoplastic agent. It is an ethyl ester, a member of furans, a C-nitro compound, a member of pyrazolidines and a benzoate ester.
Biochem/physiol Actions
PYR-41 is a cell permeable inhibitor of Ubiquitin activating enzyme (E1) with little or no activity against E3, E2, or caspase enzymatic activity.
in vitro
in addition to blocking ubiquitylation, pyr-41 was found to increase total sumoylation in cells. pyr-41 could attenuate cytokine-mediated nuclear factor-kbactivation. this correlated with inhibition of nonproteasomal ubiquitylation of traf6, which is important to ikbkinase activation. pyr-41 also prevented the downstream ubiquitylation and proteasomal degradation of ikba. moreover, pyr-41 has demonstrated effective uae e1 inhibition as well as some off-target inhibition of the other ubiquitin regulatory enzymes and signal-transducing proteins, suggesting it is a nonspecific inhibitor [1].
storage
Store at -20°C
References
1) Yang et al. (2007), Inhibitors of Ubiquitin-Activating Enzyme (E1), a New Class of Potential Cancer Therapeutics; Cancer Res., 67 9472 2) Mi et al. (2009), Cancer Preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes; J. Biol. Chem., 284 17039 3) Maehama et al. (2014), Nucleolar Stress Induces Ubiquitination-independent Proteasomal Degradation of PICT1 Protein PYR41; J. Biol. Chem., 289 20802 [Focus Citation]
PYR 41 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PYR 41 manufacturers
- Product
- PYR 41 418805-02-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25