PYR 41
- Product Name
- PYR 41
- CAS No.
- 418805-02-4
- Chemical Name
- PYR 41
- Synonyms
- PYR 41;CS-1129;PYR 41, >=98%;PYR41; PYR-41;PYR-41 ，S7129;PYR 41 USP/EP/BP;PYR-41, 10 mM in DMSO;PYR-41, Ubiquitin-activating enzyme (E1) inhibitor;Ethyl 4-(4-((5-nitrofuran-2-yl)methylene)-3,5-dioxopyrazolidin-1-yl)benzoate;ethyl 4-[(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl]benzoate
- CBNumber
- CB62535692
- Molecular Formula
- C17H13N3O7
- Formula Weight
- 371.3
- MOL File
- 418805-02-4.mol
PYR 41 Property
- Melting point:
- 228 - 235°C
- Density
- 1.486±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO at 5mg/ml with warming
- form
- powder
- pka
- 7.43±0.20(Predicted)
- color
- red to brown
- Sensitive
- Light Sensitive
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
- InChI
- InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)
- InChIKey
- ARGIPZKQJGFSGQ-LCYFTJDESA-N
- SMILES
- C(OCC)(=O)C1=CC=C(N2C(=O)C(=CC3=CC=C([N+]([O-])=O)O3)C(=O)N2)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- N2915
- Product name
- PYR-41
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $103
- Updated
- 2025/07/31
- Product number
- N2915
- Product name
- PYR-41
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $313
- Updated
- 2025/07/31
- Product number
- 15226
- Product name
- PYR41
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 15226
- Product name
- PYR41
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $51
- Updated
- 2024/03/01
- Product number
- 15226
- Product name
- PYR41
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $90
- Updated
- 2024/03/01
PYR 41 Chemical Properties,Usage,Production
Description
Pyr41 (418805-02-4) inhibits ubiquitin activating enzyme E1 (>60% inhibition at 10 μM) with little or no activity against E2 or E3. Cell permeable
Uses
PYR 41 is an irreversible and cell-permeable UBE1 inhibitor.
Definition
ChEBI: PYR-41 is an ethyl ester resulting from the formal condensation of the carboxy group of 4-{4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl}benzoic acid with ethanol. It is an irreversible and cell-permeable inhibitor of ubiquitin-activating enzyme E1. It has a role as an EC 6.2.1.45 (E1 ubiquitin-activating enzyme) inhibitor and an antineoplastic agent. It is an ethyl ester, a member of furans, a C-nitro compound, a member of pyrazolidines and a benzoate ester.
Biochem/physiol Actions
PYR-41 is a cell permeable inhibitor of Ubiquitin activating enzyme (E1) with little or no activity against E3, E2, or caspase enzymatic activity.
in vitro
in addition to blocking ubiquitylation, pyr-41 was found to increase total sumoylation in cells. pyr-41 could attenuate cytokine-mediated nuclear factor-kbactivation. this correlated with inhibition of nonproteasomal ubiquitylation of traf6, which is important to ikbkinase activation. pyr-41 also prevented the downstream ubiquitylation and proteasomal degradation of ikba. moreover, pyr-41 has demonstrated effective uae e1 inhibition as well as some off-target inhibition of the other ubiquitin regulatory enzymes and signal-transducing proteins, suggesting it is a nonspecific inhibitor [1].
storage
Store at -20°C
References
[1] YILI YANG. Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.[J]. Cancer research, 2007, 67 19: 9472-9481. DOI:10.1158/0008-5472.can-07-0568
[2] LIXIN MI. Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.[J]. The Journal of Biological Chemistry, 2009, 284 25: 17039-17051. DOI:10.1074/jbc.m901789200
[3] TOMOHIKO MAEHAMA. Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein.[J]. The Journal of Biological Chemistry, 2014, 289 30: 20802-20812. DOI:10.1074/jbc.m114.571893
PYR 41 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PYR 41 manufacturers
- Product
- PYR 41 418805-02-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25