NSC697923
Background- Product Name
- NSC697923
- CAS No.
- 343351-67-7
- Chemical Name
- NSC697923
- Synonyms
- NSC697923;NSC697923 USP/EP/BP;2-Nitro-5-tosylfuran;NSC697923, 10 mM in DMSO;NSC697923, UBE2N inhibitor;UbcH13 Inhibitor, NSC697923;2-Nitro-5-(toluene-4-sulfonyl)-furan;2-[(4-Methylphenyl)sulfonyl]-5-nitrofur;2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran;Furan, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-
- CBNumber
- CB62666859
- Molecular Formula
- C11H9NO5S
- Formula Weight
- 267.25786
- MOL File
- 343351-67-7.mol
NSC697923 Property
- Melting point:
- 124-126°C
- Boiling point:
- 443.8±40.0 °C(Predicted)
- Density
- 1.416±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
- InChI
- 1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3
- InChIKey
- GAUHIPWCDXOLCZ-UHFFFAOYSA-N
- SMILES
- [S](=O)(=O)(c2[o]c(cc2)[N+](=O)[O-])c1ccc(cc1)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0618
- Product name
- NSC697923
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $73.2
- Updated
- 2026/03/19
- Product number
- SML0618
- Product name
- NSC697923
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $257
- Updated
- 2026/03/19
- Product number
- 662107
- Product name
- UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem
- Purity
- The UbcH13 Inhibitor, NSC697923 controls the biological activity of UbcH13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
- Packaging
- 25MG
- Price
- $242
- Updated
- 2026/03/19
- Product number
- 15346
- Product name
- NSC 697923
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $23
- Updated
- 2024/03/01
- Product number
- 15346
- Product name
- NSC 697923
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
NSC697923 Chemical Properties,Usage,Production
Description
NSC-69723 (343351-67-7) is a selective inhibitor of the E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3Induces neuroblastoma cell death via activation of p53 and JNK.4
Uses
NSC 697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A and exhibits potent cytotoxicity in a panel of Neuroblastoma (NB) cell lines. NSC 697923 also inhibits the proliferation and survival of diffuse large B-cell lymphoma cells (DLBCL).
in vivo
NSC697923 (5mg/kg; i.p.; daily for 10 days) suppresses NB tumor growth in SH-SY5Y and NGP xenografts[1].
| Animal Model: | 5- to 6-week-old female athymic Ncr nude mice (orthotopic mouse model of NB; SH-SY5Y and NGP xenografts)[1] |
| Dosage: | 5mg/kg |
| Administration: | I.p.; daily for 10 days |
| Result: | Significant tumor regression in both SH-SY5Y and NGP xenografts. |
storage
+4°C
Background
NSC-697923 is a small-molecule inhibitor of the E2 ubiquitin-conjugating enzyme Ubc13-Uev1A. NSC-697923 blocked formation of Ubc13 and ubiquitin thioester conjugates, and suppressed constitutive NF-κB activity in diffuse large B cell lymphoma cells. Inhibition of ubiquitin-dependent DNA damage signaling was observed, but not formation of the phosphorylated form of histone variant H2AX, which is consistent with NSC-697923 targeting of nuclear Ubc13. Additional data suggested that NSC-697923 interacted with the Ubc13 active site cysteine. UBE2N is an E2 ubiquitin-conjugating enzyme that catalyzes K63-linked poly-Ub chain formation. UBE2N forms a heterodimer with MMS2 or Uev1A to exert its E2 ligase function. NSC-697923 treatment of neuroblastoma cells increased apoptosis and nuclear p53 accumulation, and enhanced tumor suppression. NSC-697923 also inhibited caspase-1 enzymatic activity and NLRP3 protein expression by suppressing the NF-κB signaling pathway. NSC-697923 inhibited joint swelling and NLRP3 inflammasome activation in an animal model of gouty arthritis.
References
[1] MARY PULVINO. Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.[J]. Blood, 2012, 120 8: 1668-1677. DOI:10.1182/blood-2012-02-406074
[2] SAM STRICKSON. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.[J]. Biochemical Journal, 2013, 451 3: 427-437. DOI:10.1042/bj20121651
[3] CURTIS D. HODGE. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting[J]. ACS Chemical Biology, 2015, 10 7: 1718-1728. DOI:10.1021/acschembio.5b00222
[4] J CHENG. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways[J]. Cell Death & Disease, 2014, 5 2: e1079-e1079. DOI:10.1038/cddis.2014.54
NSC697923 Preparation Products And Raw materials
Raw materials
Preparation Products
NSC697923 Suppliers
- Tel
- 021-51320588
- Fax
- 0086-21-51320502
- tauto@tautobiotech.com
- Country
- China
- ProdList
- 3988
- Advantage
- 66
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39999
- Advantage
- 60
- Tel
- 021-24206007 13764915196
- Fax
- 86-021-23027023
- sales@balmxy.com
- Country
- China
- ProdList
- 6921
- Advantage
- 55
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4827
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 86249
- Advantage
- 60
- Tel
- 857-239-0968
- Fax
- 857-239-8801
- service1@targetmol.com
- Country
- United States
- ProdList
- 2559
- Advantage
- 60
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Country
- China
- ProdList
- 29661
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58