YM155
- Product Name
- YM155
- CAS No.
- 781661-94-7
- Chemical Name
- YM155
- Synonyms
- M155;YM155;CS-35;Sepantronium;YM155, >=98%;YM-155;YM 155;YM155 USP/EP/BP;SepantroniuM broMide;Survivin Inhibitor YM155;YM-155, survivin inhibitor
- CBNumber
- CB92506237
- Molecular Formula
- C20H19BrN4O3
- Formula Weight
- 443.29386
- MOL File
- 781661-94-7.mol
YM155 Property
- Melting point:
- >180°C (dec.)
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- form
- solid
- color
- Tan to yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChI
- InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
- InChIKey
- QBIYUDDJPRGKNJ-UHFFFAOYSA-M
- SMILES
- c12[n+](Cc3nccnc3)c(C)[n](CCOC)c1C(=O)c1ccccc1C2=O.[Br-]
Safety
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML4129
- Product name
- YM155
- Purity
- ≥97% (HPLC)
- Packaging
- 1 unit
- Price
- $399
- Updated
- 2025/07/31
- Product number
- 574662
- Product name
- Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem
- Purity
- The Survivin Inhibitor, YM155, also referenced under CAS 781661-94-7, controls the biological activity of Survivin.
- Packaging
- 10MG
- Price
- $155
- Updated
- 2022/05/15
- Product number
- 11490
- Product name
- YM-155
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 11490
- Product name
- YM-155
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 11490
- Product name
- YM-155
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2024/03/01
YM155 Chemical Properties,Usage,Production
Description
YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1?Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2?Induces DNA damage.3?YM-155 induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4
Uses
YM155 is a potent IAP (inhibitor of apoptosis proteins) inhibitor for survivin with IC50 of 0.54 nM.
Uses
YM155 is a novel small-molecule survivin suppressant that suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC. cell lines. Potent Survivin Inhibitor.
Definition
ChEBI: Sepantronium bromide is an organic bromide salt consisting of sepantronium cations and bromide anions. It has been found to selectively inhibit survivin (BIRC5) gene promoter activity and to down-regulate survivin in vitro, so leading to induction of apoptosis. It has a role as an antineoplastic agent, a survivin suppressant and an apoptosis inducer. It contains a sepantronium.
target
Survivin
storage
Store at -20°C
References
[1] TAKAHITO NAKAHARA. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts.[J]. Cancer research, 2007, 67 17: 8014-8021. DOI:10.1158/0008-5472.can-07-1343
[2] K. OKAMOTO. Overcoming Erlotinib Resistance in EGFR Mutation-Positive Non-Small-Cell Lung Cancer Cells by Targeting Survivin[J]. Annals of Oncology, 2012, 23 1. DOI:10.1016/s0923-7534(20)32199-2
[3] TREVOR G GLAROS. The “survivin suppressants” NSC 80467 and YM155 induce a DNA damage response.[J]. Cancer Chemotherapy and Pharmacology, 2012: 207-212. DOI:10.1007/s00280-012-1868-0
[4] YU-FAN WANG. Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma[J]. Apoptosis, 2013, 19 4: 748-758. DOI:10.1007/s10495-013-0960-1
YM155 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from YM155 manufacturers
- Product
- YM155 781661-94-7
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-12