Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate

Product Name: Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate
CAS No.: 902589-96-2
Chemical Name: Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate
Synonyms: YMU1;Thymidylate Kinase Inhibitor, YMU1;Thymidylate Kinase Inhibitor, YMU1 - CAS 902589-96-2 - Calbiochem;Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate;YMU 1,inhibit,YMU-1,YMU1,Thymidylate Kinase Inhibitor, YMU1,Inhibitor,Thymidylate Kinase Inhibitor, YMU-1;4-[2-(4,6-Dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl]-1-piperazinecarboxylic acid ethyl ester;1-Piperazinecarboxylic acid, 4-[2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl]-, ethyl ester
CBNumber: CB52751080
Molecular Formula: C17H22N4O4S
Formula Weight: 378.45
MOL File: 902589-96-2.mol

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Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate Property

storage temp.: 2-8°C
solubility: DMSO: soluble1mg/mL, clear (warmed)
form: White solid
color: white to light brown

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0815
Product name: YMU1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $96.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 606015
Product name: Thymidylate Kinase Inhibitor, YMU1
Packaging: 10mg
Price: $154
Updated: 2023/01/07

Cayman Chemical

Product number: 21981
Product name: YMU1
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 21981
Product name: YMU1
Packaging: 10mg
Price: $134
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0815
Product name: YMU1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $491
Updated: 2025/07/31

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Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate Chemical Properties,Usage,Production

Uses

YMU1 is a potent, reversible, and ATP-competitive inhibitor of human Thymidylate kinase (TMPK).

Biological Activity

YMU1 is a cell-permeable and nontoxic inhibitor of hTMPK (thymidylate kinase) th at sensitizes tumor cells to doxorubicin in vitro and in vivo.

in vivo

YMU1 (5 mg/kg, intraperitoneal injection, three times a week, for 25 days) and doxorubicin co-administered to mice inhibits tumor growth^[1].
YMU1 (3-10 mg/kg, intraperitoneal injection, once every two days, for 30 days) inhibits the growth of A549 xenograft tumors in mice^[2].

Animal Model:	HCT-116 p53-/- cell transplantation model in nude mice^[1]
Dosage:	5 mg/kg; 3 times a week; 25 days
Administration:	Intraperitoneal injection (i.p.)
Result:	Showed that tumors grew significantly slower in mice treated with doxorubicin.

Animal Model:	A549 nude mouse transplantation model^[2]
Dosage:	3,10 mg/kg; once every two days; 30 days
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced tumor volume and weight in a dose-dependent manner.

IC 50

STAT3

Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate Suppliers

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902589-96-2, Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylateRelated Search:

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4-[2-(4,6-Dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl]-1-piperazinecarboxylic acid ethyl ester

Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate

YMU1

Thymidylate Kinase Inhibitor, YMU1

Thymidylate Kinase Inhibitor, YMU1 - CAS 902589-96-2 - Calbiochem

1-Piperazinecarboxylic acid, 4-[2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl]-, ethyl ester

YMU 1,inhibit,YMU-1,YMU1,Thymidylate Kinase Inhibitor, YMU1,Inhibitor,Thymidylate Kinase Inhibitor, YMU-1

902589-96-2