BTP2
- Product Name
- BTP2
- CAS No.
- 223499-30-7
- Chemical Name
- BTP2
- Synonyms
- BTP2;BPT2;CS-2404;YM-5883;YM-58483;YM-58483(BTP2);YM58483; YM 58483; BPT2;CRAC Channel Inhibitor, BTP2;CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem;N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
- CBNumber
- CB7204025
- Molecular Formula
- C15H9F6N5OS
- Formula Weight
- 421.32
- MOL File
- 223499-30-7.mol
BTP2 Property
- Melting point:
- 165-167 °C
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- pka
- 10.53±0.70(Predicted)
- form
- Solid
- color
- white to beige
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y4895
- Product name
- YM-58483
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $215
- Updated
- 2024/03/01
- Product number
- 13246
- Product name
- YM-58483
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 13246
- Product name
- YM-58483
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- Y4895
- Product name
- YM-58483
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $771
- Updated
- 2024/03/01
- Product number
- 13246
- Product name
- YM-58483
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $264
- Updated
- 2024/03/01
BTP2 Chemical Properties,Usage,Production
Uses
CRAC Channel Inhibitor BTP2 is a cell-permeable analog of BTP. A pyrazole derivative which inhibits activation-induced Ca2+ influx in rats.
General Description
A cell-permeable pyrazole that acts as a more potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 590 nM by Fura-2; peak current density pA/pF = -1.13 and -7.50, respectively, with or without 3 μM BTP2/Pyr2 by whole cell clamp) than the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) inTRPC3-expressing HEK293 cells (IC50 = 4.21 μM by Fura-2; pA/pF = -1.54 and -18.50, respectively, with or without 3 μM BTP2/Pyr2). A great complement to Pyr 3 (Cat. No. 648490), Pyr6, and Pyr10 in Ca2+ signaling studies.
Biological Activity
ym 58483, also known as btp2, is a soce blocker. soce has been found in macrophages, basophils, dendritic cells, and mast cells as well as t cells. the soce-related channels include the ca2+ release-activated ca2+ (crac) channel which is a highly ca2+-selective channel, and the non-selective, ca2+-permeable transient receptor potential (trp) channels, which regulate the activation of non-excitable cells such as lymphocytes. ym 58483 has been reported to inhibit cytokine production and proliferation in t cells, and may serve as a potential medicinal candidate for treatment of bronchial asthma.1. ohga k, takezawa r, arakida y, et al. characterization of ym-58483/btp2, a novel store-operated ca2+ entry blocker, on t cell-mediated immune responses in vivo. international immunopharmacology, 2008, 8(13-14): 1787-1792.2. ishikawa j, ohga k, yoshino t, et al. a pyrazole derivative, ym-58483, potently inhibits store-operated sustained ca2+ influx and il-2 production in t lymphocytes. journal of immunology, 2003, 170(9): 4441-4449.
Biochem/physiol Actions
YM-58483 is a selective Ca++ release-activated Ca++ (CRAC) [a.k.a. store-operated Ca++ (SOC) channels] that mediate Ca++ influx in T cells and other inflammatory cells. CRAC channel inhibitors have potential clinical applications in autoimmune disease, transplant rejection, allergic airway inflammation and bronchial asthma. YM-58483 is also promoted as a tool for CRAC studies; may be used as a gold standard.
storage
Store at +4°C
BTP2 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BTP2 manufacturers
- Product
- BTP2 223499-30-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23