BTP2

ChemicalBook > CAS DataBase List > BTP2

Product Name: BTP2
CAS No.: 223499-30-7
Chemical Name: BTP2
Synonyms: BTP2;BPT2;CS-2404;YM-5883;YM-58483;YM-58483(BTP2);YM58483; YM 58483; BPT2;CRAC Channel Inhibitor, BTP2;CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem;N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
CBNumber: CB7204025
Molecular Formula: C15H9F6N5OS
Formula Weight: 421.32
MOL File: 223499-30-7.mol

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BTP2 Property

Melting point:: 165-167 °C
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
pka: 10.53±0.70(Predicted)
form: Solid
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y4895
Product name: YM-58483
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $215
Updated: 2024/03/01

Cayman Chemical

Product number: 13246
Product name: YM-58483
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 13246
Product name: YM-58483
Purity: ≥98%
Packaging: 5mg
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y4895
Product name: YM-58483
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $771
Updated: 2024/03/01

Cayman Chemical

Product number: 13246
Product name: YM-58483
Purity: ≥98%
Packaging: 10mg
Price: $264
Updated: 2024/03/01

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BTP2 Chemical Properties,Usage,Production

Uses

CRAC Channel Inhibitor BTP2 is a cell-permeable analog of BTP. A pyrazole derivative which inhibits activation-induced Ca2+ influx in rats.

General Description

A cell-permeable pyrazole that acts as a more potent blocker of Stim1 and Orai1-coupled CRAC (Ca²⁺ release-activated Ca²⁺) channel-mediated SOCE (store-operated Ca^{2+ entry) in RBL-2H3 cells (IC₅₀ = 590 nM by Fura-2; peak current density pA/pF = -1.13 and -7.50, respectively, with or without 3 μM BTP2/Pyr2 by whole cell clamp) than the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca²⁺ entry) inTRPC3-expressing HEK293 cells (IC₅₀ = 4.21 μM by Fura-2; pA/pF = -1.54 and -18.50, respectively, with or without 3 μM BTP2/Pyr2). A great complement to Pyr 3 (Cat. No. 648490), Pyr6, and Pyr10 in Ca^{2+ signaling studies.}}

Biological Activity

ym 58483, also known as btp2, is a soce blocker. soce has been found in macrophages, basophils, dendritic cells, and mast cells as well as t cells. the soce-related channels include the ca2+ release-activated ca2+ (crac) channel which is a highly ca2+-selective channel, and the non-selective, ca2+-permeable transient receptor potential (trp) channels, which regulate the activation of non-excitable cells such as lymphocytes. ym 58483 has been reported to inhibit cytokine production and proliferation in t cells, and may serve as a potential medicinal candidate for treatment of bronchial asthma.1. ohga k, takezawa r, arakida y, et al. characterization of ym-58483/btp2, a novel store-operated ca2+ entry blocker, on t cell-mediated immune responses in vivo. international immunopharmacology, 2008, 8(13-14): 1787-1792.2. ishikawa j, ohga k, yoshino t, et al. a pyrazole derivative, ym-58483, potently inhibits store-operated sustained ca2+ influx and il-2 production in t lymphocytes. journal of immunology, 2003, 170(9): 4441-4449.

Biochem/physiol Actions

YM-58483 is a selective Ca++ release-activated Ca++ (CRAC) [a.k.a. store-operated Ca++ (SOC) channels] that mediate Ca++ influx in T cells and other inflammatory cells. CRAC channel inhibitors have potential clinical applications in autoimmune disease, transplant rejection, allergic airway inflammation and bronchial asthma. YM-58483 is also promoted as a tool for CRAC studies; may be used as a gold standard.

storage

Store at +4°C

BTP2 Preparation Products And Raw materials

Raw materials

Preparation Products

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BTP2 Suppliers

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View Lastest Price from BTP2 manufacturers

Career Henan Chemical Co

Product: BTP2 223499-30-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

223499-30-7, BTP2Related Search:

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BTP2

N-[4-[3,5-BIS(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]PHENYL]-4-METHYL-1,2,3-THIADIAZOLE-5-CARBOXAMIDE

4-methyl-4μ-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide

YM-58483

BTP 2, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide

YM-5883

CRAC Channel Inhibitor, BTP2

YM-58483(BTP2)

BPT2

YM58483; YM 58483; BPT2

CS-2404

N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide

CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem

1,2,3-Thiadiazole-5-carboxamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-

inhibit,CRAC Channel,Ca2+ release-activated Ca2+ channels,BTP 2,Calcium release-activated channels,YM58483,Inhibitor,YM-58483,BTP-2

223499-30-7

C15H9F6N5OS