ChemicalBook > CAS DataBase List > YM-53601

YM-53601

Product Name
YM-53601
CAS No.
182959-33-7
Chemical Name
YM-53601
Synonyms
YM-53601 Exclusive;YM-53601 hydrochloride;(E)-2-(2-Fluoro-2-(quinuclidin-3-ylidene)ethoxy)-9H-carbazole hydrochloride;2-[(2E)-2-(1-azabicyclo[2.2.2]octan-3-ylidene)-2-fluoroethoxy]-9H-carbazole:hydrochloride;2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride;9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1)
CBNumber
CB2972954
Molecular Formula
C21H21FN2O.ClH
Formula Weight
372.869
MOL File
182959-33-7.mol
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YM-53601 Property

Melting point:
236.5-237.2 °C
storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 2 mg/ml
form 
A crystalline solid
color 
Off-white to light brown
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Safety

Safety Statements 
22-24/25
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18113
Product name
YM-53601
Purity
≥98%
Packaging
500μg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
18113
Product name
YM-53601
Purity
≥98%
Packaging
1mg
Price
$388
Updated
2024/03/01
Cayman Chemical
Product number
18113
Product name
YM-53601
Purity
≥98%
Packaging
5mg
Price
$1631
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
INB0005643
Product name
2-((2E)-2-(1-AZABICYCLO(2.2.2)OCT-3-YLIDENE)-2-FLUOROETHOXY)-9H-CARBAZOLE, MONOHYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$657
Updated
2021/12/16
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YM-53601 Chemical Properties,Usage,Production

Uses

YM-53601 is a squalene synthetase inhibitor.

Definition

ChEBI: YM-53601 is a member of carbazoles.

Biological Activity

Squalene synthase inhibitor.


YM-53601 is a cell penetrant and potent squalene synthase inhibitor inhibits cholesterol biosynthesis in rodents. YM-53601 lowers cholesterol levels and triglyceride levels better than HMG-CoA reductase inhibitor (prevastatin) and fibrate (fenofibrate.).

in vivo

YM-53601 suppresses cholesterol biosynthesis in rats (ED50, 32?mg/kg)[1].
YM-53601 also reduces plasma non-HDL cholesterol levels in hamsters by approximately 70% at an oral dose of 50 mg/kg/day for 5 days[2].
YM-53601 potentiates Doxorubicin-mediated hepatocellular carcinoma cells (HCC) growth arrest and cell death in vivo[4].

Animal Model:Sprague-Dawley (SD) rats weighing 150-170?g[1]
Dosage:6.25, 12.5, 25 or 50?mg/kg
Administration:Given a single p.o.
Result:Inhibited cholesterol biosynthesis from acetate in a dose-dependent manner in rats. The ED50?value for YM-53601 cholesterol biosynthesis inhibition is 32? mg/kg.
Animal Model:Five- to six-week-old male BALB/c athymic (nu/nu) nude mice[4]
Dosage:15 mg/kg
Administration:2 wk of daily treatment by p.o. gavage
Result:Significantly decreased the intratumor cholesterol levels.

YM-53601 Preparation Products And Raw materials

Raw materials

Preparation Products

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YM-53601 Suppliers

China 27 Switzerland 1 United States 5 Global 33
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18146
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56
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71829
Advantage
60
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32251
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq：1580084073
Email
1580084073@qq.com
Country
China
ProdList
809
Advantage
58

182959-33-7, YM-53601Related Search:

YME1L1 siRNA (m) (R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA YM155 YM 26734 1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride BTP2 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide YM17E

  • 2-[(2E)-2-(1-azabicyclo[2.2.2]octan-3-ylidene)-2-fluoroethoxy]-9H-carbazole:hydrochloride
  • 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride
  • YM-53601 Exclusive
  • 9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1)
  • (E)-2-(2-Fluoro-2-(quinuclidin-3-ylidene)ethoxy)-9H-carbazole hydrochloride
  • YM-53601 hydrochloride
  • 182959-33-7
  • C21H21FN2OHCl