1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride

Product Name: 1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride
CAS No.: 355406-09-6
Chemical Name: 1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride
Synonyms: YM-155 HCl;YM-155 (chloride);YM155 hydrochloride;YM 155 hydrochloride;YM-155 (hydrochloride);YM-155 HCl (Sepantronium HCl);YM155 HYDROCHLORIDE;YM 155 HYDROCHLORIDE;1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride
CBNumber: CB82623698
Molecular Formula: C20H19ClN4O3
Formula Weight: 398.85
MOL File: 355406-09-6.mol

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1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride Property

storage temp.: Store at -20°C
solubility: ≥19.45 mg/mL in DMSO; ≥4.34 mg/mL in EtOH with gentle warming and ultrasonic; ≥48.1 mg/mL in H2O with ultrasonic
form: solid
color: Light brown to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3947
Product name: YM-155hydrochloride
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ApexBio Technology

Product number: A3947
Product name: YM-155hydrochloride
Packaging: 10mM(in 1mL DMSO)
Price: $70
Updated: 2021/12/16

ApexBio Technology

Product number: A3947
Product name: YM-155hydrochloride
Packaging: 10mg
Price: $85
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611822
Product name: YM-155 hydrochloride
Packaging: 10mg
Price: $171.7
Updated: 2021/12/16

ApexBio Technology

Product number: A3947
Product name: YM-155hydrochloride
Packaging: 25mg
Price: $190
Updated: 2021/12/16

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1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride Chemical Properties,Usage,Production

Uses

Sepantronium hydrochloride (YM-155 hydrochloride) is a novel survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity[1].

in vivo

Sepantronium bromide (YM155; 3 and 10 mg/kg) inhibits the tumor growth in PC-3 xenografts, without obvious body weight loss and blood cell count decrease. Sepantronium bromide is highly distributed to tumor tissue in vivo. Sepantronium bromide shows 80% TGI at a dose of 5 mg/kg in PC-3 orthotopic xenografts^[1].
Sepantronium bromide (YM155) in combination with γ-radiation shows potent antitumor activity against H460 or Calu6 xenografts in nude mice^[2].
In this orthotopic renal and metastatic lung tumors models, Sepantronium bromide (YM-155) and IL-2 additively decreases tumor weight, lung metastasis, and luciferin-stained tumor images^[3].

target

survivin

References

[1] Nakahara T, et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 2007 Sep 1;67(17):8014-21. DOI:10.1158/0008-5472.CAN-07-1343
[2] Iisa T, et al. Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin Cancer Res. 2008 Oct 15;14(20):6496-504. DOI:10.1158/1078-0432.CCR-08-0468
[3] Guo K, et al. A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model. Oncotarget. 2015 Aug 28;6(25):21137-47. DOI:10.18632/oncotarget.4121

1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride Suppliers

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SPIRO PHARMA

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355406-09-6, 1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chlorideRelated Search:

YM155 YM 26734 BTP2 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate YM-53601 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide YM17E

1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride

YM 155 hydrochloride

YM-155 (hydrochloride)

YM155 hydrochloride

YM-155 HCl

YM155 HYDROCHLORIDE;YM 155 HYDROCHLORIDE

YM-155 (chloride)

YM-155 HCl (Sepantronium HCl)

355406-09-6