Motesanib

Product Name: Motesanib
CAS No.: 453562-69-1
Chemical Name: Motesanib
Synonyms: D06678;CS-1108;motesanib;Motesanib Base;AMG 706; AMG-706;AMG-706(Motesanib);Motesanib (AMG-706) Base);2,4-Imidazolidinedione,5-(3-bromophenyl)-6-methyl-;N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide;N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide,AMG706
CBNumber: CB01518524
Molecular Formula: C22H23N5O
Formula Weight: 373.45
MOL File: 453562-69-1.mol

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Motesanib Property

Melting point:: 147-150°C
Boiling point:: 517.3±50.0 °C(Predicted)
Density: 1.251
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
form: White powder solid.
pka: 11.75±0.40(Predicted)
color: Pale Yellow

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M732500
Product name: Motesanib
Packaging: 50mg
Price: $165
Updated: 2021/12/16

Usbiological

Product number: 017881
Product name: Motesanib
Packaging: 5mg
Price: $496
Updated: 2021/12/16

Adipogen Life Sciences

Product number: SYN-1055-M100
Product name: Motesanib
Purity: ≥95%
Packaging: 100mg
Price: $1069
Updated: 2021/12/16

AK Scientific

Product number: X4931
Product name: Motesanib
Packaging: 500mg
Price: $1265
Updated: 2021/12/16

Matrix Scientific

Product number: 132644
Product name: N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide
Purity: 97%
Packaging: 250mg
Price: $630
Updated: 2021/12/16

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Motesanib Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.

Uses

Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.

Definition

ChEBI: Motesanib is a pyridinecarboxamide.

target

VEGFR1

Motesanib Preparation Products And Raw materials

Raw materials

Preparation Products

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Motesanib Suppliers

Canada 1 China 119 Germany 1 India 2 United Kingdom 3 United States 18 Global 144

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4602
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
Fax: QQ:115820162
Email: sales@zhiwe.net
Country: China
ProdList: 608
Advantage: 61

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Xi’an chemsoar Medical Technology Co., ltd

Tel: 029-86538357
Fax: 029-87871708
Country: China
ProdList: 234
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Beijing Yisiyan Technology Research Center

Tel: 010-56645598 13366904824
Fax: 01062230033
Email: bjkaida@163.com
Country: China
ProdList: 1637
Advantage: 59

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View Lastest Price from Motesanib manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: motesanib 453562-69-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: Motesanib 453562-69-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kgs
Release date: 2020-01-02

453562-69-1, MotesanibRelated Search:

Xylene Imiquimod Dacthal Dimethyl fumarate N,N-Dimethylformamide Dimethyl carbonate Dimethyl sulfoxide Dimethyl sulfate Dimethyl phthalate Dimethyl ether ETHANE 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE Compound 23 ERK Inhibitor 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID Motesanib

CS-1108

AMG 706; AMG-706

N-(3,3-diMethylindolin-6-yl){2-[(4-pyridylMethyl)-aMino](3-pyridyl)}-carboxaMide

3-PyridinecarboxaMide, N-(2,3-dihydro-3,3-diMethyl-1H-indol-6-yl)-2-[(4-pyridinylMethyl)aMino]-

Motesanib Base

AMG-706(Motesanib)

Motesanib (AMG-706) Base)

motesanib

N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide

N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide

N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide,AMG706

D06678

2,4-Imidazolidinedione,5-(3-bromophenyl)-6-methyl-

453562-69-1

API

Inhibitors

Antineoplastic