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ERK Inhibitor

Product Name
ERK Inhibitor
CAS No.
1049738-54-6
Chemical Name
ERK Inhibitor
Synonyms
ERK-IN-4;ERK Inhibitor - CAS 1049738-54-6 - Calbiochem;3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride;(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride
CBNumber
CB13136749
Molecular Formula
C14H17ClN2O3S
Formula Weight
328.81
MOL File
1049738-54-6.mol
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ERK Inhibitor Property

storage temp. 
+2C to +8C
solubility 
DMSO: 2 mg/ml
form 
Light yellow solid
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15944
Product name
ERK Inhibitor
Purity
≥95%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15944
Product name
ERK Inhibitor
Purity
≥95%
Packaging
1mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
15944
Product name
ERK Inhibitor
Purity
≥95%
Packaging
5mg
Price
$117
Updated
2024/03/01
AK Scientific
Product number
9473CW
Product name
ErkInhibitor
Packaging
5mg
Price
$228
Updated
2021/12/16
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ERK Inhibitor Chemical Properties,Usage,Production

Description

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 μM), A549 lung carcinoma cells (IC50 = 25 μM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

General Description

A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 μM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.

Biochem/physiol Actions

Primary TargetERK

ERK Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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ERK Inhibitor Suppliers

Shanghai Run-Biotech Co., Ltd.
Tel
021-57171705 13817537615
Fax
QQ3095748324
Email
sales@run-biotech.com
Country
China
ProdList
2445
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
7982
Advantage
58

1049738-54-6, ERK InhibitorRelated Search:


  • (5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride
  • ERK Inhibitor - CAS 1049738-54-6 - Calbiochem
  • 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride
  • ERK-IN-4
  • 1049738-54-6