Glycogen Phosphorylase Inhibitor

Product Name: Glycogen Phosphorylase Inhibitor
CAS No.: 648926-15-2
Chemical Name: Glycogen Phosphorylase Inhibitor
Synonyms: Glycogen phosphorylase-IN-1;Glycogen Phosphorylase Inhibitor;Glycogen Phosphorylase Inhibitor inhibitor;2-chloro-4,5-difluoro-N-[[2-methoxy-5-(methylcarbamoylamino)phenyl]carbamoyl]benzamide;Benzamide, 2-chloro-4,5-difluoro-N-[[[2-methoxy-5-[[(methylamino)carbonyl]amino]phenyl]amino]carbonyl]-
CBNumber: CB83136788
Molecular Formula: C17H15ClF2N4O4
Formula Weight: 412.78
MOL File: 648926-15-2.mol

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Glycogen Phosphorylase Inhibitor Property

Density: 1.490±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:5.0(Max Conc. mg/mL);12.11(Max Conc. mM)
DMSO:5.0(Max Conc. mg/mL);12.11(Max Conc. mM)
form: White powder solid.
pka: 8.47±0.46(Predicted)
color: white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 361515
Product name: Glycogen Phosphorylase Inhibitor - CAS 648926-15-2 - Calbiochem
Purity: The Glycogen Phosphorylase Inhibitor, also referenced under CAS 648926-15-2, controls the biological activity of Glycogen Phosphorylase.
Packaging: 1MG
Price: $134
Updated: 2025/07/31

Cayman Chemical

Product number: 17578
Product name: Glycogen Phosphorylase Inhibitor
Purity: ≥98%
Packaging: 1mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 17578
Product name: Glycogen Phosphorylase Inhibitor
Purity: ≥98%
Packaging: 5mg
Price: $410
Updated: 2024/03/01

TRC

Product number: G641000
Product name: GlycogenPhosphorylaseInhibitor
Packaging: 25mg
Price: $1375
Updated: 2021/12/16

AK Scientific

Product number: 5355CR
Product name: GlycogenPhosphorylaseInhibitor
Packaging: 1mg
Price: $206
Updated: 2021/12/16

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Glycogen Phosphorylase Inhibitor Chemical Properties,Usage,Production

Description

Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC₅₀ = 53 nM). It blocks glucagon-induced hepatic glycogenolysis in vivo. Glycogen phosphorylase inhibitor has been used to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells.

Uses

Glycogen Phosphorylase Inhibitor is used in biological studies to evaluate glycogen utilization in human liver HepG2 cells.

in vivo

Glycogen phosphorylase-IN-1 (5 mg/kg, i.v., single dose) inhibits the glycogenolysis in hepatocytes, ameliorates the glucagon stimulated hyperglycemic in wistar rats^[1].

Animal Model:	Glucagon-stimulated hyperglycemic in wistar rats^[1]
Dosage:	5 mg/kg
Administration:	i.v., single dose
Result:	Reduced blood glucose.

References

[1] THOMAS KLABUNDE. Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes[J]. Journal of Medicinal Chemistry, 2005, 48 20: 6178-6193. DOI: 10.1021/jm049034y
[2] ALAN CHENG. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori’s disease.[J]. Genes & development, 2007, 21 19: 2399-2409. DOI: 10.1101/gad.1553207
[3] KONSTANTINOS PAPPELIS. The retinal ganglion cells in metabolic syndrome.[J]. Annals of translational medicine, 2024, 12 1: 2. DOI: 10.21037/atm-23-1796
[4] ONETSINE ARRIZABALAGA. Rac1 protein regulates glycogen phosphorylase activation and controls interleukin (IL)-2-dependent T cell proliferation.[J]. The Journal of Biological Chemistry, 2012: 11878-11890. DOI: 10.1074/jbc.m111.297804

Glycogen Phosphorylase Inhibitor Preparation Products And Raw materials

Raw materials

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Glycogen Phosphorylase Inhibitor Suppliers

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Glycogen Phosphorylase Inhibitor

2-chloro-4,5-difluoro-N-[[2-methoxy-5-(methylcarbamoylamino)phenyl]carbamoyl]benzamide

Benzamide, 2-chloro-4,5-difluoro-N-[[[2-methoxy-5-[[(methylamino)carbonyl]amino]phenyl]amino]carbonyl]-

Glycogen Phosphorylase Inhibitor inhibitor

Glycogen phosphorylase-IN-1

648926-15-2