Chk2 Inhibitor

Product Name: Chk2 Inhibitor
CAS No.: 724708-21-8
Chemical Name: Chk2 Inhibitor
Synonyms: SC203885;SC-203885;SC 203885;Chk2 Inhibitor;Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem;Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)-
CBNumber: CB82514668
Molecular Formula: C15H13N5O2
Formula Weight: 295.3
MOL File: 724708-21-8.mol

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Chk2 Inhibitor Property

storage temp.: -20C
solubility: DMSO: Soluble
form: Pale yellow solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21184
Product name: Chk2 Inhibitor
Packaging: 500μg
Price: $242
Updated: 2024/03/01

Cayman Chemical

Product number: 21184
Product name: Chk2 Inhibitor
Packaging: 1mg
Price: $387
Updated: 2024/03/01

TRC

Product number: C263468
Product name: Chk2Inhibitor
Packaging: 1000μg
Price: $645
Updated: 2021/12/16

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Chk2 Inhibitor Chemical Properties,Usage,Production

Uses

Chk2 Inhibitor is a checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest.

General Description

A cell-permeable, ATP competitive, and reversible indoloazepine compound that displays anti-proliferative and anti-inflammatory properties. Acts as a potent inhibitor of Chk2 (IC₅₀ = 8 nM) that targets the ATP binding pocket. Exhibits selectivity for Chk2 over MEK1, Chk1, CK1δ, PKCα, PKCβII and CK2 (IC₅₀ = 89 nM, 237 nM, 1.352 μM, 2.539 μM, 3.381 μM, and >10.0 μM, respectively). Blocks the production of IL-2 and TNF-α by preventing the transcriptional activation of NF-κB (IC₅₀ = 3.55 μM for IL-2 production in PMA-stimulated Jurkat T cells; 8.16 μM for TNF-α production in LPS-stimulated THP-1 cells). Also reported to suppress the growth of leukemic T cells (GI₅₀ = 1.73 μM).

Biochem/physiol Actions

Primary TargetChk2

Chk2 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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Chk2 Inhibitor Suppliers

Canada 1 China 7 India 1 United States 7 Global 16

VDM Biochemicals

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Chk2 Inhibitor

Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem

Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)-

SC 203885

SC203885

SC-203885

724708-21-8

Cholinergics