Chk2 Inhibitor

Product Name: Chk2 Inhibitor
CAS No.: 724708-21-8
Chemical Name: Chk2 Inhibitor
Synonyms: SC203885;SC-203885;SC 203885;Chk2 Inhibitor;Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem;Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)-
CBNumber: CB82514668
Molecular Formula: C15H13N5O2
Formula Weight: 295.3
MOL File: 724708-21-8.mol

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Chk2 Inhibitor Property

storage temp.: -20C
solubility: DMSO: Soluble
form: Pale yellow solid
color: pale yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 220485-M
Product name: Chk2 Inhibitor
Purity: The Chk2 Inhibitor, also referenced under CAS 724708-21-8, controls the biological activity of Chk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applic
Packaging: 100 mg
Price: $95.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 220485-M
Product name: Chk2 Inhibitor
Purity: The Chk2 Inhibitor, also referenced under CAS 724708-21-8, controls the biological activity of Chk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applic
Packaging: 1 unit
Price: $291
Updated: 2025/07/31

Cayman Chemical

Product number: 21184
Product name: Chk2 Inhibitor
Packaging: 500μg
Price: $242
Updated: 2024/03/01

Cayman Chemical

Product number: 21184
Product name: Chk2 Inhibitor
Packaging: 1mg
Price: $387
Updated: 2024/03/01

TRC

Product number: C263468
Product name: Chk2Inhibitor
Packaging: 1000μg
Price: $645
Updated: 2021/12/16

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Chk2 Inhibitor Chemical Properties,Usage,Production

Uses

Chk2 Inhibitor is a checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest.

General Description

A cell-permeable, ATP competitive, and reversible indoloazepine compound that displays anti-proliferative and anti-inflammatory properties. Acts as a potent inhibitor of Chk2 (IC₅₀ = 8 nM) that targets the ATP binding pocket. Exhibits selectivity for Chk2 over MEK1, Chk1, CK1δ, PKCα, PKCβII and CK2 (IC₅₀ = 89 nM, 237 nM, 1.352 μM, 2.539 μM, 3.381 μM, and >10.0 μM, respectively). Blocks the production of IL-2 and TNF-α by preventing the transcriptional activation of NF-κB (IC₅₀ = 3.55 μM for IL-2 production in PMA-stimulated Jurkat T cells; 8.16 μM for TNF-α production in LPS-stimulated THP-1 cells). Also reported to suppress the growth of leukemic T cells (GI₅₀ = 1.73 μM).

Biochem/physiol Actions

Primary TargetChk2

IC 50

Chk2: 13.5 nM (IC₅₀); Chk1: 220.4 nM (IC₅₀)

Chk2 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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Chk2 Inhibitor Suppliers

Canada 1 China 18 India 1 United States 7 Global 27

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7982
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Merck Millipore

Tel: 1-400-889-1988 400-889-1988
Email: bioscience@merckgroup.com
Country: China
ProdList: 6839
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

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Chk2 Inhibitor

Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem

Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)-

SC 203885

SC203885

SC-203885

724708-21-8

Cholinergics