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Chk2 Inhibitor

Product Name
Chk2 Inhibitor
CAS No.
724708-21-8
Chemical Name
Chk2 Inhibitor
Synonyms
SC203885;SC-203885;SC 203885;Chk2 Inhibitor;Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem;Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)-
CBNumber
CB82514668
Molecular Formula
C15H13N5O2
Formula Weight
295.3
MOL File
724708-21-8.mol
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Chk2 Inhibitor Property

storage temp. 
-20C
solubility 
DMSO: Soluble
form 
Pale yellow solid
color 
pale yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
220485-M
Product name
Chk2 Inhibitor
Purity
The Chk2 Inhibitor, also referenced under CAS 724708-21-8, controls the biological activity of Chk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applic
Packaging
100 mg
Price
$95.8
Updated
2025/07/31
Sigma-Aldrich
Product number
220485-M
Product name
Chk2 Inhibitor
Purity
The Chk2 Inhibitor, also referenced under CAS 724708-21-8, controls the biological activity of Chk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applic
Packaging
1 unit
Price
$291
Updated
2025/07/31
Cayman Chemical
Product number
21184
Product name
Chk2 Inhibitor
Packaging
500μg
Price
$242
Updated
2024/03/01
Cayman Chemical
Product number
21184
Product name
Chk2 Inhibitor
Packaging
1mg
Price
$387
Updated
2024/03/01
TRC
Product number
C263468
Product name
Chk2Inhibitor
Packaging
1000μg
Price
$645
Updated
2021/12/16
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Chk2 Inhibitor Chemical Properties,Usage,Production

Uses

Chk2 Inhibitor is a checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest.

General Description

A cell-permeable, ATP competitive, and reversible indoloazepine compound that displays anti-proliferative and anti-inflammatory properties. Acts as a potent inhibitor of Chk2 (IC50 = 8 nM) that targets the ATP binding pocket. Exhibits selectivity for Chk2 over MEK1, Chk1, CK1δ, PKCα, PKCβII and CK2 (IC50 = 89 nM, 237 nM, 1.352 μM, 2.539 μM, 3.381 μM, and >10.0 μM, respectively). Blocks the production of IL-2 and TNF-α by preventing the transcriptional activation of NF-κB (IC50 = 3.55 μM for IL-2 production in PMA-stimulated Jurkat T cells; 8.16 μM for TNF-α production in LPS-stimulated THP-1 cells). Also reported to suppress the growth of leukemic T cells (GI50 = 1.73 μM).

Biochem/physiol Actions

Primary TargetChk2

IC 50

Chk2: 13.5 nM (IC50); Chk1: 220.4 nM (IC50)

Chk2 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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Chk2 Inhibitor Suppliers

Canada 1 China 18 India 1 United States 7 Global 27
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai Yiyan Biotechnology Co. , Ltd.
Tel
021-69985186 13611928337
Email
3427709316@qq.com
Country
China
ProdList
7982
Advantage
58
Merck Millipore
Tel
1-400-889-1988 400-889-1988
Email
bioscience@merckgroup.com
Country
China
ProdList
6839
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Enzo Biochem Inc
Tel
Enzo Biochem Inc. 13797054060
Email
Enzoname@qq.com
Country
China
ProdList
6174
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
Tel
027-88013699 17354350817
Email
Ryan@jiutian-bio.com
Country
China
ProdList
5949
Advantage
58
Guangzhou Chengan Biotechnology Co., Ltd.
Tel
13360184497
Country
CHINA
ProdList
104
Advantage
58
Guangzhou Haotian Biotechnology Co., Ltd.
Tel
15571990006
Country
CHINA
ProdList
122
Advantage
58
Guangzhou Yiran Biotechnology Co., Ltd.
Tel
15571990006
Country
CHINA
ProdList
141
Advantage
58
Nanjing Meisi Biotechnology Co., Ltd.
Tel
18118807185
Country
CHINA
ProdList
124
Advantage
58
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

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  • Chk2 Inhibitor
  • Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem
  • Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)-
  • SC 203885
  • SC203885
  • SC-203885
  • 724708-21-8
  • Cholinergics