Chk2 Inhibitor
- Product Name
- Chk2 Inhibitor
- CAS No.
- 724708-21-8
- Chemical Name
- Chk2 Inhibitor
- Synonyms
- SC203885;SC-203885;SC 203885;Chk2 Inhibitor;Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem;Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)-
- CBNumber
- CB82514668
- Molecular Formula
- C15H13N5O2
- Formula Weight
- 295.3
- MOL File
- 724708-21-8.mol
Chk2 Inhibitor Property
- storage temp.
- -20C
- solubility
- DMSO: Soluble
- form
- Pale yellow solid
N-Bromosuccinimide Price
- Product number
- 21184
- Product name
- Chk2 Inhibitor
- Packaging
- 500μg
- Price
- $242
- Updated
- 2024/03/01
- Product number
- 21184
- Product name
- Chk2 Inhibitor
- Packaging
- 1mg
- Price
- $387
- Updated
- 2024/03/01
- Product number
- C263468
- Product name
- Chk2Inhibitor
- Packaging
- 1000μg
- Price
- $645
- Updated
- 2021/12/16
Chk2 Inhibitor Chemical Properties,Usage,Production
Uses
Chk2 Inhibitor is a checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest.
General Description
A cell-permeable, ATP competitive, and reversible indoloazepine compound that displays anti-proliferative and anti-inflammatory properties. Acts as a potent inhibitor of Chk2 (IC50 = 8 nM) that targets the ATP binding pocket. Exhibits selectivity for Chk2 over MEK1, Chk1, CK1δ, PKCα, PKCβII and CK2 (IC50 = 89 nM, 237 nM, 1.352 μM, 2.539 μM, 3.381 μM, and >10.0 μM, respectively). Blocks the production of IL-2 and TNF-α by preventing the transcriptional activation of NF-κB (IC50 = 3.55 μM for IL-2 production in PMA-stimulated Jurkat T cells; 8.16 μM for TNF-α production in LPS-stimulated THP-1 cells). Also reported to suppress the growth of leukemic T cells (GI50 = 1.73 μM).
Biochem/physiol Actions
Primary TargetChk2