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C2 CERAMIDE

Product Name
C2 CERAMIDE
CAS No.
3102-57-6
Chemical Name
C2 CERAMIDE
Synonyms
N-ACETYLSPHINGOSINE;N-ACETYL-D-SPHINGOSINE;N-ETHANOYL-D-ERYTHRO-SPHINGOSINE;CERAMIDE C2;C2 CERAMIDE;C2:0 CERAMIDE;TOC Ceramide;ACETYL CERAMIDE;C14 SPHINGOID BASE;N-Acetylsphigosine
CBNumber
CB8342539
Molecular Formula
C20H39NO3
Formula Weight
341.53
MOL File
3102-57-6.mol
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C2 CERAMIDE Property

Melting point:
93-96 °C
Boiling point:
477.13°C (rough estimate)
Density 
1.0283 (rough estimate)
refractive index 
1.5614 (estimate)
storage temp. 
−20°C
solubility 
DMSO: soluble
form 
powder
pka
13.50±0.20(Predicted)
color 
white
Stability:
Moisture Sensitive
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29241990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
01912
Product name
N-Acetyl-D-sphingosine
Purity
≥98.0% (TLC)
Packaging
50mg
Price
$101.6
Updated
2024/03/01
Sigma-Aldrich
Product number
01912
Product name
N-Acetyl-D-sphingosine
Purity
≥98.0% (TLC)
Packaging
250mg
Price
$342.8
Updated
2024/03/01
Alfa Aesar
Product number
J60534
Product name
N-Acetyl-D-sphingosine, 98%
Packaging
5mg
Price
$112
Updated
2023/06/20
Alfa Aesar
Product number
J60534
Product name
N-Acetyl-D-sphingosine, 98%
Packaging
1mg
Price
$20.5
Updated
2021/12/16
Cayman Chemical
Product number
62510
Product name
C-2 Ceramide
Purity
≥98%
Packaging
1mg
Price
$21
Updated
2024/03/01
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C2 CERAMIDE Chemical Properties,Usage,Production

Description

C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells, induction of apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts and stimulates the growth of bovine aortic smooth muscle cells. The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.

Chemical Properties

White Crystalline Solid

Uses

Inhibits cell proliferation and induces monocytic differentiation of HL-60 cells. Activates protein phosphatases

Uses

A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2

Definition

ChEBI: N-acetylsphingosine is a N-acylsphingosine that has an acetamido group at position 2.

Biological Activity

A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro .

Biochem/physiol Actions

Cell-permeable, biologically active ceramide. It induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases.

storage

Desiccate at -20°C

References

1) Minano et al. (2008), C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3; J. Neurosci. Res., 86 1734 2) Prinetti et al. (1997), Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells; FEBS Lett., 414 475 3) Zhang et al. (1997), Kinase suppressor of Ras is ceramide-activated protein kinase; Cell, 89 63 4) Matsuzaka et al. (2016) Characterization and Functional Analysis of Extracellular Vesicles and Muscle-Abundant miRNAs (miR-1, miR-133a, and miR-206) in C2C12 Myocytes and mdx Mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation] 5) Matsuzaka et al. (2016) Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNA in C2C12 myocytes and Mdx mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation]

C2 CERAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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C2 CERAMIDE Suppliers

Shanghai Renshi Pharmatech Co., LTD
Tel
021-61150625 17721318029
Fax
021-26018649
Email
info@renshipharma.com
Country
China
ProdList
116
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Yichang Zhongyitai Trading Co., Ltd.
Tel
0717-6449896 13886658719
Fax
0717-6558598
Email
root@zhongyitai.com
Country
China
ProdList
1977
Advantage
58
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View Lastest Price from C2 CERAMIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
C2 CERAMIDE 3102-57-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-11

3102-57-6, C2 CERAMIDERelated Search:


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  • N-ACETYL-D-ERYTHRO-SPHINGOSINE
  • N-ACETYL-D-SPHINGOSINE
  • N-ACETYLSPHINGOSINE, D-ERYTHRO
  • N-ACETYLSPHINGOSINE
  • C14 SPHINGOID BASE
  • C2:0 CERAMIDE
  • C2-D-ERYTHRO-CERAMIDE
  • C2 CERAMIDE
  • C2 CERAMIDE OF D-ERYTHRO-C14-SPHINGOSINE
  • CERAMIDE C2
  • Acetamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-
  • D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem
  • D-ERYTHRO-SPHINGOSINE, N-ACETYL-
  • ACETYL CERAMIDE
  • N-ETHANOYL-D-ERYTHRO-SPHINGOSINE SYNTHE TICAL 99+%
  • N-Ethanoyl-D-erythro-sphingosine, synthetical
  • (D-erythro-N-Acetylsphingosine)
  • D-erythro-Sphingoshine, N-Acetyl-
  • N-Ethanoyl-D-sphingosine
  • TOC Ceramide
  • Acetyl ceramide, C2 ceramide
  • N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxyMethyl)-3-heptadecen-1-yl]acetaMide
  • (2S,3R,4E)-2-(Acetylamino)-4-octadecene-1,3-diol
  • C2 Ceramide (d18:1/2:0)
  • N-Acetylsphigosine
  • C2 Ceramide,C-2 Ceramide
  • 3102-57-6
  • 3102-57-5
  • 7344-2-7
  • 3101-57-6
  • BioChemical
  • Anti-Proliferative Agents
  • Antitumor Agents
  • Cancer Research
  • Mixed Fatty Acids
  • Activators
  • Fatty Acid Derivatives & Lipids
  • Glycerols
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
  • Lipid signaling