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C6 CERAMIDE

Product Name
C6 CERAMIDE
CAS No.
124753-97-5
Chemical Name
C6 CERAMIDE
Synonyms
CERAMIDE C6;C6 CERAMIDE;06:0 CERAMIDE;CAPROYL CERAMIDE;C8 SPHINGOID BASE;C6-D-ERYTHRO-CERAMIDE;N-HEXANOYLSPHINGOSINE;C6 Ceramide (d18:1/6:0);N-CAPROYL-D-SPHINGOSINE;N-HEXANOY-D-SPHINGOSINE
CBNumber
CB9744617
Molecular Formula
C24H47NO3
Formula Weight
397.63
MOL File
124753-97-5.mol
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C6 CERAMIDE Property

Melting point:
76-77°C
Boiling point:
521.03°C (rough estimate)
Density 
1.0077 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
-20°C
solubility 
Soluble in 100% ethanol at 25mg/ml and also in DMSO at 50mg/ml.
pka
13.53±0.20(Predicted)
form 
Powder
color 
White
Stability:
Freezer -20°C
LogP
7.463 (est)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29241990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
376650
Product name
N-Hexanoyl-D-sphingosine
Packaging
5mg
Price
$111
Updated
2024/03/01
Sigma-Aldrich
Product number
H6524
Product name
N-Hexanoyl-D-sphingosine
Purity
≥98% (TLC), synthetic
Packaging
1mg
Price
$40.1
Updated
2023/06/20
Alfa Aesar
Product number
J67034
Product name
C6 Ceramide
Packaging
1mg
Price
$28.7
Updated
2023/06/20
Alfa Aesar
Product number
J67034
Product name
C6 Ceramide
Packaging
5mg
Price
$100
Updated
2023/06/20
Cayman Chemical
Product number
62525
Product name
C-6 Ceramide
Purity
≥98%
Packaging
1mg
Price
$18
Updated
2024/03/01
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C6 CERAMIDE Chemical Properties,Usage,Production

Description

C6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides. C6 ceramide mediates many diverse biological activities including apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. It also enhances the expression of COX-2 in rat granulosa cells and stimulates the growth of bovine aortic smooth muscle cells. C6 ceramide acts in neuronal axons to inhibit neurite growth.

Chemical Properties

Off White Powder

Uses

A biologically active, cell permeable, but nonphysiologic ceramide analog. It stimulates protein phosphatase 2A at concentrations as low as 10 nM and activiates MAP kinase. It induces apoptosis and inhibits glycoproptein traffic by the secretory pathway.

Uses

C6 Ceramide (d18:1/6:0) has been used as a chemotherapeutic agent to test its anti-tumor effect in breast cancer cells and ovarian cancer cell lines. It has also been used to test chemo-sensitization effects in cancer cells.

Definition

ChEBI: N-(hexanoyl)sphing-4-enine is an N-acylsphingosine consisting of sphing-4-enine bearing a hexanoyl group on nitrogen. It is functionally related to a sphing-4-enine.

General Description

Biologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G0/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells.

Biochem/physiol Actions

C6 Ceramide (d18:1/6:0) is involved in inhibiting proliferation and inducing apoptosis. When used in combination with acid ceramidase inhibitor DM102, [(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivaloylamide], it favors cell death in human breast cancer cells lines. C6 Ceramide may serve as an adjunct in chemotherapy. It elicits anti-tumor effects via AKT (serine/threonine-specific protein kinase) dephosphorylation and α-tubulin acetylation.

C6 CERAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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C6 CERAMIDE Suppliers

Shanghai Renshi Pharmatech Co., LTD
Tel
021-61150625 17721318029
Fax
021-26018649
Email
info@renshipharma.com
Country
China
ProdList
118
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
Yichang Zhongyitai Trading Co., Ltd.
Tel
0717-6449896 13886658719
Fax
0717-6558598
Email
root@zhongyitai.com
Country
China
ProdList
1977
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
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View Lastest Price from C6 CERAMIDE manufacturers

BINBO BIOLOGICAL CO.,LTD
Product
C6 CERAMIDE 124753-97-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000 kg
Release date
2024-04-26

124753-97-5, C6 CERAMIDERelated Search:


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  • alpha-Hydroxyoctadecanoyl-phytosphingosine
  • D-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem
  • Hexanamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-
  • N-((2S,3R,E)-1,3-Dihydroxyoctadec-4-en-2-yl)hexanamide
  • 124753-97-5
  • C24H47NO3
  • BioChemical
  • Cancer Research
  • Antitumor Agents
  • Anti-Proliferative Agents
  • Mixed Fatty Acids
  • Fatty Acid Derivatives & Lipids
  • Glycerols
  • Inhibitors
  • Protein Kinase Inhibitors and Activators