C6 CERAMIDE

ChemicalBook > CAS DataBase List > C6 CERAMIDE

Product Name: C6 CERAMIDE
CAS No.: 124753-97-5
Chemical Name: C6 CERAMIDE
Synonyms: CERAMIDE C6;C6 CERAMIDE;06:0 CERAMIDE;CAPROYL CERAMIDE;C8 SPHINGOID BASE;C6-D-ERYTHRO-CERAMIDE;N-HEXANOYLSPHINGOSINE;C6 Ceramide (d18:1/6:0);N-CAPROYL-D-SPHINGOSINE;N-HEXANOY-D-SPHINGOSINE
CBNumber: CB9744617
Molecular Formula: C24H47NO3
Formula Weight: 397.63
MOL File: 124753-97-5.mol

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C6 CERAMIDE Property

Melting point:: 76-77°C
Boiling point:: 521.03°C (rough estimate)
Density: 1.0077 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: -20°C
solubility: Soluble in 100% ethanol at 25mg/ml and also in DMSO at 50mg/ml.
pka: 13.53±0.20(Predicted)
form: Powder
color: White
Stability:: Freezer -20°C
LogP: 7.463 (est)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 376650
Product name: N-Hexanoyl-D-sphingosine
Packaging: 5mg
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: H6524
Product name: N-Hexanoyl-D-sphingosine
Purity: ≥98% (TLC), synthetic
Packaging: 1mg
Price: $40.1
Updated: 2023/06/20

Alfa Aesar

Product number: J67034
Product name: C6 Ceramide
Packaging: 1mg
Price: $28.7
Updated: 2023/06/20

Alfa Aesar

Product number: J67034
Product name: C6 Ceramide
Packaging: 5mg
Price: $100
Updated: 2023/06/20

Cayman Chemical

Product number: 62525
Product name: C-6 Ceramide
Purity: ≥98%
Packaging: 1mg
Price: $18
Updated: 2024/03/01

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C6 CERAMIDE Chemical Properties,Usage,Production

Description

C6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides. C6 ceramide mediates many diverse biological activities including apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. It also enhances the expression of COX-2 in rat granulosa cells and stimulates the growth of bovine aortic smooth muscle cells. C6 ceramide acts in neuronal axons to inhibit neurite growth.

Chemical Properties

Off White Powder

Uses

A biologically active, cell permeable, but nonphysiologic ceramide analog. It stimulates protein phosphatase 2A at concentrations as low as 10 nM and activiates MAP kinase. It induces apoptosis and inhibits glycoproptein traffic by the secretory pathway.

Uses

C6 Ceramide (d18:1/6:0) has been used as a chemotherapeutic agent to test its anti-tumor effect in breast cancer cells and ovarian cancer cell lines. It has also been used to test chemo-sensitization effects in cancer cells.

Definition

ChEBI: N-(hexanoyl)sphing-4-enine is an N-acylsphingosine consisting of sphing-4-enine bearing a hexanoyl group on nitrogen. It is functionally related to a sphing-4-enine.

General Description

Biologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G₀/G₁ phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells.

Biochem/physiol Actions

C6 Ceramide (d18:1/6:0) is involved in inhibiting proliferation and inducing apoptosis. When used in combination with acid ceramidase inhibitor DM102, [(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivaloylamide], it favors cell death in human breast cancer cells lines. C6 Ceramide may serve as an adjunct in chemotherapy. It elicits anti-tumor effects via AKT (serine/threonine-specific protein kinase) dephosphorylation and α-tubulin acetylation.

C6 CERAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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C6 CERAMIDE Suppliers

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View Lastest Price from C6 CERAMIDE manufacturers

BINBO BIOLOGICAL CO.,LTD

Product: C6 CERAMIDE 124753-97-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000 kg
Release date: 2024-04-26

124753-97-5, C6 CERAMIDERelated Search:

GANGLIOTETRAOSYL CERAMIDE DISIALOGANGLIOSIDE GD1B 2NA 6-((N-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)AMINO)-HEXANOYL)SPHINGOSYL PHOSPHOCHOLINE GAL-BETA,3GALNAC-BETA1,4(NEU5AC-ALPHA2,3)GAL-BETA1,4GLC-BETA1,1 CERAMIDE, NH,GAL-GALNAC-GAL(SA)-GLC-CERAMIDE C6 CERAMIDE GAL(SA)-GALNAC-GAL(SA)-GLC-CERAMIDE GANGLIOTRIOSYL CERAMIDE N-[12-[(7-NITRO-2-1,3-BENZOXADIAZOL-4-YL)AMINO]DODECANOYL]-CERAMIDE GAL-BETA1,4GLC-CERAMIDE, PORCINE,GAL-BETA1,4GLC-CERAMIDE,LACTOSYL CERAMIDE, BOVINE,LACTOSYL CERAMIDE,LACTOSYL CERAMIDE, PORCINE LIGNOCERIC CERAMIDE LYSO-LACTOSYL CERAMIDE LIGNOCERIC CERAMIDE LYSO-CERAMIDE TRIHEXOSIDE Phytosphingosine D-ERYTHRO-SPHINGOSINE N-LIGNOCEROYL-D-SPHINGOSINE 1-BENZOATE NERVONIC CERAMIDE N-ARACHIDOYL-D-ERYTHRO-SPHINGOSINE

N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxyMethyl)-3-heptadecen-1-yl]hexanaMide

C6 Ceramide (d18:1/6:0)

N-HEXANOYL-D-ERYTHRO-SPHINGOSINE;C6 CERAMIDE (D18:1/6:0)

6-Hexanoyl-D-erythro-sphingosine, 99+%

C6 ceramide, Caproyl ceramide, N-Caproyl-D-sphingosine

6-HEXANOYL-D-ERYTHRO-SPHINGOSINE, SYNTHETICAL, 99+%

6-Hexanoyl-D-erythro-sphingosine, synthetical

6-Hexanoyl-D-erythro-sphingosine,99+%,synthetical

6-Hexanoyl-D-erythro-sphingosineCeramide C6

CAPROYL CERAMIDE

CERAMIDE C6

C6 CERAMIDE OF D-ERYTHRO-C8-SPHINGOSINE

C6 CERAMIDE

C6-D-ERYTHRO-CERAMIDE

C8 SPHINGOID BASE

D-ERYTHRO-SPHINGOSINE, N-HEXANOYL-

06:0 CERAMIDE

6-HEXANOYL-D-ERYTHRO-SPHINGOSINE

N-CAPROYL-C18-SPHINGOSINE

N-CAPROYL-D-SPHINGOSINE

N-HEXANOYL-D-ERYTHRO-SPHINGOSINE

N-HEXANOY-D-SPHINGOSINE

N-HEXANOYLSPHINGOSINE

N-HEXANOYLSPHINGOSINE, D-ERYTHRO

N-HEXANOYL-D-SPHINGOSINE

N-HEXANOYL-D-SPHINGOSINE FROM SYNTHETIC D-SPHINGOSINE

alpha-Hydroxyoctadecanoyl-phytosphingosine

D-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem

Hexanamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-

124753-97-5

C24H47NO3

BioChemical

Cancer Research

Antitumor Agents

Anti-Proliferative Agents

Mixed Fatty Acids

Fatty Acid Derivatives & Lipids

Glycerols

Inhibitors

Protein Kinase Inhibitors and Activators