GANGLIOSIDE GD1A DISODIUM SALT
- Product Name
- GANGLIOSIDE GD1A DISODIUM SALT
- CAS No.
- 12707-58-3
- Chemical Name
- GANGLIOSIDE GD1A DISODIUM SALT
- Synonyms
- GD1A;GD1A 2NA;Ganglioside B1;Ganglioside GII;GANGLIOSIDE GD1A;GD1A-GANGLIOSIDE;disialogangloside GD1a;DISIALOGANGLIOSIDE GD1A;DISIALOGANGLIOSIDE GDIA;GD1a-Ganglioside sodium
- CBNumber
- CB2218829
- Molecular Formula
- C84H146N4Na2O39
- Formula Weight
- 1882.04098
- MOL File
- 12707-58-3.mol
GANGLIOSIDE GD1A DISODIUM SALT Property
- storage temp.
- -20°C
- solubility
- DMSO: soluble
- form
- lyophilized powder
- BRN
- 6228822
N-Bromosuccinimide Price
- Product number
- G2392
- Product name
- Disialoganglioside GD1a from bovine brain
- Purity
- ≥95% (TLC), lyophilized powder
- Packaging
- 1mg
- Price
- $148
- Updated
- 2025/07/31
- Product number
- G2392
- Product name
- Disialoganglioside GD1a from bovine brain
- Purity
- ≥95% (TLC), lyophilized powder
- Packaging
- 5mg
- Price
- $653.6
- Updated
- 2025/07/31
- Product number
- 15585
- Product name
- Ganglioside GD1a (sodium salt)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 15585
- Product name
- Ganglioside GD1a (sodium salt)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $262
- Updated
- 2024/03/01
- Product number
- G235070
- Product name
- GangliosideGD1aDisodiumSalt
- Packaging
- 1mg
- Price
- $195
- Updated
- 2021/12/16
GANGLIOSIDE GD1A DISODIUM SALT Chemical Properties,Usage,Production
Description
Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver. It can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis. Ganglioside GD1a (20 μM) also increases endothelial cell proliferation. Furthermore, ganglioside GD1a has been shown to act as a functional coreceptor for toll-like receptor 2 (TLR2), enabling the recruitment of TLR2 to lipid rafts when bound by a bacterial toxin. Ganglioside GD1a mixture contains ganglioside GD1a molecular species with C18:1 and C20:1 sphingoid backbones.
Chemical Properties
White powder
Uses
Ganglioside GD1a Disodium Salt is an agent with a stimulatory effect on phagocytosis and phagosome-lysosome.
General Description
Ganglioside GD1a is an anionic brain ganglioside. It is localized in the inner and outer membrane of nuclear envelope of the neuronal cells. GD1a contains a neutral tetrasaccharide core, with one or two sialic acid on the internal galactose. It also has an additional sialic acid on the non-reducing terminal of galactose.
References
[1] PURNA MUKHERJEE. Thematic review series: sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a.[J]. Journal of Lipid Research, 2008: 929-938. DOI: 10.1194/jlr.r800006-jlr200
[2] SHUANG LIANG. Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin.[J]. The Journal of Biological Chemistry, 2007, 282 10: 7532-7542. DOI: 10.1074/jbc.m611722200
[3] M IWAMORI. Gangliosides of various rat tissues: distribution of ganglio-N-tetraose-containing gangliosides and tissue-characteristic composition of gangliosides.[J]. Journal of biochemistry, 1984, 95 3: 761-770. DOI: 10.1093/oxfordjournals.jbchem.a134667
[4] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[5] WALKLEY S U. Secondary accumulation of gangliosides in lysosomal storage disorders[J]. Seminars in cell & developmental biology, 2004, 15 4: Pages 433-444. DOI: 10.1016/j.semcdb.2004.03.002
GANGLIOSIDE GD1A DISODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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