MIF Antagonist, ISO-1
- Product Name
- MIF Antagonist, ISO-1
- CAS No.
- 478336-92-4
- Chemical Name
- MIF Antagonist, ISO-1
- Synonyms
- ISO-1;CS-1195;ISO-1 (ISO 1;MIF Antagonist;ISO-1, 10 mM in DMSO;ISO-1, MIF Antagonist;MIF Antagonist, ISO-1;ISO 1;ISO1;MIF ANTAGONIST;ISO-1,Inhibitor,ISO1,inhibit;ISO 1, MIF-Antagonist, MIF antagonist
- CBNumber
- CB62521242
- Molecular Formula
- C12H13NO4
- Formula Weight
- 235.24
- MOL File
- 478336-92-4.mol
MIF Antagonist, ISO-1 Property
- Melting point:
- 114 °C
- Boiling point:
- 365.0±48.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO.
- pka
- 9.22±0.30(Predicted)
- form
- Light yellow crystalline solid.
- color
- Off-white
- Sensitive
- Light Sensitive
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- InChI
- InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3
- InChIKey
- AIXMJTYHQHQJLU-UHFFFAOYSA-N
- SMILES
- O1C(CC(OC)=O)CC(C2=CC=C(O)C=C2)=N1
N-Bromosuccinimide Price
- Product number
- 5.05225
- Product name
- InSolution MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem
- Packaging
- 10MG
- Price
- $220
- Updated
- 2025/07/31
- Product number
- 475837
- Product name
- MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem
- Purity
- The MIF Antagonist, ISO-1, also referenced under CAS 478336-92-4, controls the biological activity of MIF.
- Packaging
- 5MG
- Price
- $148
- Updated
- 2025/07/31
- Product number
- I1119
- Product name
- ISO-1
- Packaging
- 5MG
- Price
- $77
- Updated
- 2025/07/31
- Product number
- I1119
- Product name
- ISO-1
- Packaging
- 25MG
- Price
- $229
- Updated
- 2025/07/31
- Product number
- 14929
- Product name
- MIF Antagonist
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
MIF Antagonist, ISO-1 Chemical Properties,Usage,Production
Description
ISO-1 (478336-92-4) is an antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis.1 Inhibits airway remodeling in mouse asthma model.2 ISO-1 also blocks MIF-induced autophagy.3?Active in cellular and mouse models.
Uses
MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 μM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. MIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.
in vivo
ISO-1 (injected intraperitoneally; 3.5-35 mg/kg; twice daily; 2 weeks) improves the survival rate from lethal endotoxemia and shows the anti-inflammatory effect[2]. ISO-1 (intraperitoneal injection; 35 mg/kg; twice daily; 3 days) causes a significant reduction in average implant size and decreases Flk1 expression in implants[3].
| Animal Model: | C57Bl/6 MIF+/+ and MIF–/– mice[2] |
| Dosage: | 3.5-35 mg/kg |
| Administration: | Injected intraperitoneally; 3.5-35 mg/kg; twice a day ; 2 weeks |
| Result: | Was protective against lethal sepsis. |
| Animal Model: | Female C57BL/6-Tg(ACTB-EGFP)1Osb/J mice[3] |
| Dosage: | 35 mg/kg |
| Administration: | Intraperitoneal injection; 35 mg/kg; twice daily; 3 days |
| Result: | Reduced average endometriotic implant size. |
storage
Store at +4°C
References
[1] YOUSEF AL-ABED. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis.[J]. The Journal of Biological Chemistry, 2005, 280 44: 36541-36544. DOI:10.1074/jbc.c500243200
[2] PEI-FEN CHEN. ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma.[J]. Molecular Medicine, 2010, 16 9-10: 400-408. DOI:10.2119/molmed.2009.00128
[3] YUNG-CHUN CHUANG. Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation.[J]. ACS Applied Bio Materials, 2012: e37613. DOI:10.1371/journal.pone.0037613
MIF Antagonist, ISO-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from MIF Antagonist, ISO-1 manufacturers
- Product
- MIF Antagonist, ISO-1 478336-92-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22