MIF Antagonist, ISO-1

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MIF Antagonist, ISO-1

Product Name: MIF Antagonist, ISO-1
CAS No.: 478336-92-4
Chemical Name: MIF Antagonist, ISO-1
Synonyms: ISO-1;CS-1195;ISO-1 (ISO 1;MIF Antagonist;ISO-1, MIF Antagonist;MIF Antagonist, ISO-1;ISO 1;ISO1;MIF ANTAGONIST;ISO-1,Inhibitor,ISO1,inhibit;Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate;4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester
CBNumber: CB62521242
Molecular Formula: C12H13NO4
Formula Weight: 235.24
MOL File: 478336-92-4.mol

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MIF Antagonist, ISO-1 Property

Melting point:: 114 °C
Boiling point:: 365.0±48.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO.
pka: 9.22±0.30(Predicted)
form: Light yellow crystalline solid.
color: Off-white
Sensitive: Light Sensitive
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.05225
Product name: InSolution MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem
Packaging: 10MG
Price: $214
Updated: 2024/03/01

Sigma-Aldrich

Product number: 475837
Product name: MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem
Purity: The MIF Antagonist, ISO-1, also referenced under CAS 478336-92-4, controls the biological activity of MIF.
Packaging: 5MG
Price: $144
Updated: 2024/03/01

TCI Chemical

Product number: I1119
Product name: ISO-1
Packaging: 5MG
Price: $85
Updated: 2024/03/01

TCI Chemical

Product number: I1119
Product name: ISO-1
Packaging: 25MG
Price: $254
Updated: 2024/03/01

Alfa Aesar

Product number: J64947
Product name: MIF Antagonist, ISO-1
Packaging: 5mg
Price: $114
Updated: 2023/06/20

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MIF Antagonist, ISO-1 Chemical Properties,Usage,Production

Description

ISO-1 (478336-92-4) is an antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis.1 Inhibits airway remodeling in mouse asthma model.2 ISO-1 also blocks MIF-induced autophagy.3?Active in cellular and mouse models.

Uses

MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 μM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. MIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.

storage

Store at +4°C

References

1) Al-Abed et al. (2005), ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis; J. Biol. Chem., 280 2) Chen et al. (2010), ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma; Mol. Med., 16 400 3) Chuang et al. (2012), Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation; PLoS One, 7 e37613

MIF Antagonist, ISO-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MIF Antagonist, ISO-1 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: MIF Antagonist, ISO-1 478336-92-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

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MIF Antagonist, ISO-1

Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate

ISO-1

MIF Antagonist

4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester

CS-1195

ISO-1, MIF Antagonist

ISO-1 (ISO 1

ISO 1;ISO1;MIF ANTAGONIST

5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester

2-[3-(4-Hydroxyphenyl)-4,5-dihydroisoxazol-5-yl]acetic Acid Methyl Ester

ISO-1,Inhibitor,ISO1,inhibit

478336-92-4